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https://open.uns.ac.rs/handle/123456789/2251
Поље DC-а | Вредност | Језик |
---|---|---|
dc.contributor.author | Edita Stokić | en_US |
dc.contributor.author | Andrea Romani | en_US |
dc.contributor.author | Branislava Ilinčić | en_US |
dc.contributor.author | Aleksandar Kupusinac | en_US |
dc.contributor.author | Zoran Stošić | en_US |
dc.contributor.author | Esma Isenović | en_US |
dc.date.accessioned | 2019-09-23T10:20:27Z | - |
dc.date.available | 2019-09-23T10:20:27Z | - |
dc.date.issued | 2018-01-01 | - |
dc.identifier.issn | 15701611 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/2251 | - |
dc.description.abstract | © 2018 Bentham Science Publishers. Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators [insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD)-0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH)D), vitamin D deficiency <50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH)D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg <0.85 mmol/L), a negative linear coefficient was found between 25(OH)D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg ≥0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Current Vascular Pharmacology | en_US |
dc.subject | Obesity | en_US |
dc.subject | cardiometabolic risk indicators | en_US |
dc.subject | chronic latent magnesium deficiency | en_US |
dc.subject | insulin resistance | en_US |
dc.subject | micronutrients | en_US |
dc.subject | vitamin D deficiency | en_US |
dc.title | Chronic latent magnesium deficiency in obesity decreases positive effects of vitamin D on cardiometabolic risk indicators | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.2174/1570161115666170821154841 | - |
dc.identifier.pmid | 16 | - |
dc.identifier.scopus | 2-s2.0-85039731695 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85039731695 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 617 | en_US |
dc.relation.firstpage | 610 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 16 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Katedra za internu medicinu | - |
crisitem.author.dept | Katedra za patološku fiziologiju i laboratorijsku medicinu | - |
crisitem.author.dept | Departman za računarstvo i automatiku | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
Налази се у колекцијама: | FTN Publikacije/Publications |
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