Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке:
https://open.uns.ac.rs/handle/123456789/2192
Назив: | Mimetic Hierarchical Approaches for Osteochondral Tissue Engineering | Аутори: | Gađanski, Ivana | Датум издавања: | апр-2018 | Издавач: | Springer | Часопис: | Advances in Experimental Medicine and Biology | Сажетак: | In order to engineer biomimetic osteochondral (OC) construct, it is necessary to address both the cartilage and bone phase of the construct, as well as the interface between them, in effect mimicking the developmental processes when generating hierarchical scaffolds that show gradual changes of physical and mechanical properties, ideally complemented with the biochemical gradients. There are several components whose characteristics need to be taken into account in such biomimetic approach, including cells, scaffolds, bioreactors as well as various developmental processes such as mesenchymal condensation and vascularization, that need to be stimulated through the use of growth factors, mechanical stimulation, purinergic signaling, low oxygen conditioning, and immunomodulation. This chapter gives overview of these biomimetic OC system components, including the OC interface, as well as various methods of fabrication utilized in OC biomimetic tissue engineering (TE) of gradient scaffolds. Special attention is given to addressing the issue of achieving clinical size, anatomically shaped constructs. Besides such neotissue engineering for potential clinical use, other applications of biomimetic OC TE including formation of the OC tissues to be used as high-fidelity disease/healing models and as in vitro models for drug toxicity/efficacy evaluation are covered. | URI: | https://open.uns.ac.rs/handle/123456789/2192 | ISSN: | 0065-2598 | DOI: | 10.1007/978-3-319-76711-6_7 |
Налази се у колекцијама: | IBS Publikacije/Publications |
Приказати целокупан запис ставки
SCOPUSTM
Навођења
6
проверено 15.03.2024.
Преглед/и станица
13
Протекла недеља
10
10
Протекли месец
0
0
проверено 03.05.2024.
Google ScholarTM
Проверите
Алт метрика
Ставке на DSpace-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.