Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/2148
Nаziv: | Methylation status of p16 and p14 genes in locally advanced rectal cancer: Potential clinical implication | Аutоri: | Bojana Kožik Nikola Kokanov Slavica Knežević Ušaj Ivan Nikolić Radoslav Davidović Snežana Jovanović Ćupić Milena Krajnović |
Ključnе rеči: | rectal cancer;DNA methylation;biomarkers;VEGF;EGFR;p16;p14 | Dаtum izdаvаnjа: | 1-јан-2018 | Čаsоpis: | Archives of Biological Sciences | Sažetak: | © 2018 by the Serbian Biological Society. Methylation of p16 and p14 genes is a common event in colorectal cancers; however, their exact role in the prediction of patients' outcome is unclear. We conducted this retrospective study to evaluate their potential predictive and/or prognostic roles. Methylation-specific PCR was used to examine the methylation status of p16 and p14 in pretherapeutic and preoperative biopsy specimens of 60 patients with locally advanced rectal cancer. The methylation status of the examined genes did not affect the response to preoperative chemoradiotherapy (CRT), recurrence rate and overall survival. However, patients with a simultaneous presence of either p16 or p14 methylation and high vascular endothelial growth factor (VEGF) expression showed a significantly worse response to CRT (p=0.005 and p=0.038, respectively). Moreover, patients with both p16 methylation and high VEGF expression had significantly shorter overall survival (p=0.010), while no such association was found in patients with p14 methylation and high VEGF expression. On the other hand, a subgroup of patients with p16 methylation and low VEGF and high epidermal growth factor receptor (EGFR) expression showed a significantly better response to CRT (p=0.024). The obtained results point to the importance of p16 and p14 methylation analyses in combination with VEGF and EGFR expression, aimed at better predicting treatment response and patient outcome. | URI: | https://open.uns.ac.rs/handle/123456789/2148 | ISSN: | 3544664 | DOI: | 10.2298/ABS180316030K |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
1
prоvеrеnо 20.05.2023.
Prеglеd/i stаnicа
28
Prоtеklа nеdеljа
9
9
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.