Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/2127
Title: Influence of decreased fibrinolytic activity and plasminogen activator inhibitor-1 4G/5G polymorphism on the risk of venous thrombosis
Authors: Biljana Vučković 
Mirjana Đerić 
Branko Tomić
Valentina Đorđević
Branislav Bajkin 
Gorana Mitić 
Keywords: venous thrombosis;risk factors;fibrinolytic activity;plasminogen activator inhibitor
Issue Date: 1-Jan-2018
Journal: Blood Coagulation and Fibrinolysis
Abstract: © 2018 Wolters Kluwer Health, Inc. All rights reserved. Objective of our study is to determine whether decreased fibrinolytic activity or plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism influence the risk of venous thrombosis. Our case-control study included 100 patients with venous thrombosis, and 100 random controls. When patients were compared with random controls, unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs). Decreased fibrinolytic activity yielded a 2.7-fold increase in risk for venous thrombosis than physiological fibrinolytic activity (OR 2.70; 95% CI 1.22-5.98), when comparing patients with random controls. Adjustment for several putative confounders did not change the estimate (OR 3.02; 95% CI 1.26-7.22). Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20). Decreased fibrinolytic activity increased, whereas PAI-1 4G/ 5G polymorphism did not influence venous thrombosis risk in this study.
URI: https://open.uns.ac.rs/handle/123456789/2127
ISSN: 9575235
DOI: 10.1097/MBC.0000000000000656
Appears in Collections:MDF Publikacije/Publications

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