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https://open.uns.ac.rs/handle/123456789/20415
Title: | Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract | Authors: | Karaman Maja Janjušević Ljiljana Jakovljević Dragica Šibul Filip |
Issue Date: | 2019 | Journal: | Natural Product Research | Abstract: | © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine. | URI: | https://open.uns.ac.rs/handle/123456789/20415 | ISSN: | 1478-6419 | DOI: | 10.1080/14786419.2017.1422183 |
Appears in Collections: | PMF Publikacije/Publications |
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