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https://open.uns.ac.rs/handle/123456789/19469
Nаziv: | Asymmetric synthesis of the cytotoxic lactone (+)-cardiobutanolide and two novel analogues | Аutоri: | Kovačević Ivana Popsavin Mirjana Rodić Marko Kojic Vesna Popsavin Velimir |
Dаtum izdаvаnjа: | 2019 | Čаsоpis: | Tetrahedron Letters | Sažetak: | © 2019 Elsevier Ltd A new asymmetric synthesis of the naturally occurring styryl lactone cardiobutanolide and two novel analogues have been achieved starting from D-xylose. The key steps of the synthesis included an initial zinc mediated reductive THF-ring opening, stereoselective olefination and Sharpless asymmetric dihydroxylation. It was shown that cardiobutanolide (1) exhibits promising in vitro antitumour properties against certain human neoplastic cell lines. It was more potent than the commercial anticancer agent doxorubicin against three cell lines (K562, HL-60 and Raji). | URI: | https://open.uns.ac.rs/handle/123456789/19469 | ISSN: | 0040-4039 | DOI: | 10.1016/j.tetlet.2019.01.059 |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications |
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