Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/19332
Nаziv: | Chromatographic lipophilicity and pharmacokinetic behavior of some newly synthesized styryl lactonestereoisomers | Аutоri: | Lončar, Davor Milošević, Nataša Vitas, Jasmina Karadžić Banjac, Milica Jevrić, Lidija Benedeković, Goran |
Dаtum izdаvаnjа: | 2017 | Izdаvаč: | Novi Sad: University of Novi Sad, Faculty of Technology Novi Sad | Čаsоpis: | Acta Periodica Technologica | Sažetak: | The RP-HPLC retention constants of several newly synthesized cytotoxic styryl lactone stereoisomers were determined as parameters of their lipophilicity. Stereochemistry of the compounds has an effect on the retention behavior of only tricyclic isomers. For them, the difference in retention and chromatographic lipophilic parameters are significant. The chromatographic lipophilic parameters of all compounds were correlated with a fourteen computer calculated lipophilic parameters, log P, and pharmacokinetic parameters. Significant linear correlations (R2adj>0.90) were obtained between MLog P and affinity for plasma proteins binding. The correrelations for the other pharmacokinetic parameters were improved by introducing some more molecular descriptors. Multiple linear regression analysis suggested that the volume of distribution depended on the lipopholicity and KaHSA (HSA-human serum albumin) and the absorption through membrane and permeability in the jejunum depend on the lipophilicity and hydrogen bond donors. The tested compounds showed a potent to moderate cytotoxic activity toward several human cancer cells and poor permeation through the blood brain barrier. | URI: | https://open.uns.ac.rs/handle/123456789/19332 | ISSN: | 14507188 | DOI: | 10.2298/APT1748197L (BISIS)109804 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications TF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
Prеglеd/i stаnicа
34
Prоtеklа nеdеljа
8
8
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.