Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/19206
Nаziv: | Newly Synthesized Heteronuclear Ruthenium(II)/Ferrocene Complexes Suppress the Growth of Mammary Carcinoma in 4T1-Treated BALB/c Mice by Promoting Activation of Antitumor Immunity | Аutоri: | Milutinović, Milan Čanović, Petar Stevanović, Dragana Masnikosa, Romana Vraneš, Milan Aleksandar, Tot Zarić, Milan M. Simović Marković, Bojana Misirkić Marjanović, Maja Vučićević, Ljubica Savić, Maja Jakovljević, Vladimir Trajković, Vladimir Volarević, Vladislav Kanjevac, Tatjana Rilak Simović, Ana |
Dаtum izdаvаnjа: | 2018 | Čаsоpis: | Organometallics | Sažetak: | Copyright © 2018 American Chemical Society. The two new heterometallic Ru(II)-tpy/ferrocene complexes [Ru(tpy)Cl2(mtefc)] (1) and [Ru(tpy)Cl2(mtpfc)] (2) (where tpy = 2,2′:6′,2′′-terpyridine, mtefc = (2-(methylthio)ethyl)ferrocene, and mtpfc = (3-(methylthio)propyl)ferrocene) have been synthesized and then characterized through elemental analysis, followed by various spectroscopic (IR, UV-vis, 1D and 2D NMR) and mass spectrometric techniques (MALDI TOF and ESI Q-TOF MS). UV-vis and fluorescence spectroscopy and viscometry were employed to study the interactions of the complexes 1 and 2 with calf thymus DNA. Both 1 and 2 expelled ethidium bromide (EB) from the EB/DNA complex (Ksv = (1.5-1.8) × 104 M-1), which suggested that the complexes intercalated into the double helix of DNA. Both complexes strongly quenched the fluorescence of tryptophan residues in serum albumin through both static and dynamic quenching. Molecular docking confirmed the intercalative mode of complex interaction with DNA. The docking results implied that 1 and 2 interacted with hydrophobic residues of albumin, particularly with those lying in the proximity of Tyr 160. We here demonstrate the high cytotoxic potential of complexes 1 and 2 against the breast cancer cells that originated either from humans (MDA-MB-231) or from mice (4T1), with apoptosis being the main mechanism of complex-induced cell death. It is worth noting that both complexes promoted activation of innate and acquired antitumor immunity, which contributed to the reduced growth and progression of mammary carcinoma in vivo. | URI: | https://open.uns.ac.rs/handle/123456789/19206 | ISSN: | 0276-7333 | DOI: | 10.1021/acs.organomet.8b00604 (BISIS)109427 |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
18
prоvеrеnо 12.08.2023.
Prеglеd/i stаnicа
72
Prоtеklа nеdеljа
8
8
Prоtеkli mеsеc
1
1
prоvеrеnо 03.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.