Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/17705
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Karadžić Banjac, Milica | en_US |
dc.contributor.author | Jevrić, Lidija | en_US |
dc.contributor.author | Mandić, Anamarija | en_US |
dc.contributor.author | Markov, Siniša | en_US |
dc.contributor.author | Podunavac-Kuzmanović, Sanja | en_US |
dc.contributor.author | Kovačević, Strahinja | en_US |
dc.contributor.author | Nikolić (Gaković), Andrea | en_US |
dc.contributor.author | Oklješa, Aleksandar | en_US |
dc.contributor.author | Sakač, Marija | en_US |
dc.contributor.author | Penov-Gaši, Katarina | en_US |
dc.date.accessioned | 2020-12-13T12:02:26Z | - |
dc.date.available | 2020-12-13T12:02:26Z | - |
dc.date.issued | 2017-07-15 | - |
dc.identifier.issn | 09280987 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/17705 | - |
dc.description.abstract | © 2017 Elsevier B.V. Physicochemical characterization of steroid analogs (triazole, tetrazole, toluenesulfonylhydrazide, nitrile, dinitrile and dione) is considered to be a very important step in further drug selection. This study applies to the determination of lipophilicity of previously synthesized steroid derivatives using reversed-phase high-performance liquid chromatography (RP HPLC). Chemometric aspect of chromatographic lipophilicity is given throughout multiple linear regression (MLR) quantitative structure-retention relationships (QSRR) approach. Minimal inhibitory concentration (MIC) is determined for two steroid derivatives possessing antimicrobial activity against Staphylococcus aureus. Molecular docking study was performed in order to identify the compound with the most promising potential as human cytochrome P450 CYP17A1inhibitor. Identified 3β-hydroxyandrost-5-eno[16,17-d]-1,2,3-triazole (I.2.) could be recommended for further trials for anticancer drugs and subjected to the absorption, distribution, metabolism, excretion and toxicity (ADMET) evaluation. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | European Journal of Pharmaceutical Sciences | en_US |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | Chemometrics approach based on chromatographic behavior, in silico characterization and molecular docking study of steroid analogs with biomedical importance | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.ejps.2017.05.004 | - |
dc.identifier.doi | (BISIS)104603 | - |
dc.identifier.doi | (BISIS)104603 | - |
dc.identifier.pmid | 105 | - |
dc.identifier.scopus | 2-s2.0-85019115578 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=104603&source=BEOPEN&language=en | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85019115578 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 81 | en_US |
dc.relation.firstpage | 71 | en_US |
dc.relation.volume | 105 | en_US |
dc.identifier.externalcrisreference | (BISIS)104603 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za primenjene i inženjerske hemije | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za primenjene i inženjerske hemije | - |
crisitem.author.dept | Naučni institut za prehrambene tehnologije u Novom Sadu | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za primenjene i inženjerske hemije | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za primenjene i inženjerske hemije | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0002-0514-4033 | - |
crisitem.author.orcid | 0000-0001-7925-6815 | - |
crisitem.author.orcid | 0000-0002-5492-7237 | - |
crisitem.author.orcid | 0000-0002-4269-9206 | - |
crisitem.author.orcid | 0000-0002-5619-9894 | - |
crisitem.author.orcid | 0000-0002-1097-5800 | - |
crisitem.author.orcid | 0000-0002-2796-1296 | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
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