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https://open.uns.ac.rs/handle/123456789/1695
Title: | The relationship between the vitamin serum 25(OH)D and the B12 concentrations in Obese women | Authors: | Nikola Ćurić Branislava Ilinčić Nataša Milić Velibor Čabarkapa Stanislava Nikolić Milica Medić Stojanoska Rinaldo Pellicano Ludovico Abenavoli |
Keywords: | Vitamin D;Vitamin B 12;Micronutrients;Deficiency | Issue Date: | 1-Apr-2018 | Journal: | Minerva Medica | Abstract: | © 2017 EDIZIONI MINERVA MEDICA. BACKGROUND: In obesity, low levels of Vitamin D (VD) and vitamin B12 (VB12) may be the result of different pathophysiological mechanisms, but the possible association between them has not been defined yet. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyVitamin D (25(OH)D) and VB12 levels in middle aged women. METHODS: In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis. Vitamin D and VB12 status was assessed by laboratory measurement [serum 25(OH)D levels by electrochemiluminescent immunoassay; VB12 by chemiluminescent microparticle immunoassay]. RESULTS: Obese women were mostly VD deficient [25(OH)D below 50 nmol/L; 40/50, 80%]. Also, among obese we observed presence of VB12 deficiency [VB12 below 148 pmol/L; 13/50, 26%) and marginal depletion of VB12 level (marginal VB12 status 148-221 pmol/L; 20/50, 40%). All anthropometric indicators of obesity, ECV and TBW were significantly associated with both, 25(OH)D and VB12 (P<.001) levels. In univariate regression analysis serum level of 25(OH)D was significantly associated with VB12 levels (R 2 =0.170, P<0.001). In regression models, 25(OH)D was significantly associated with VB12 level, independently of fat mass and extracellular fluid volume. CONCLUSIONS: Obesity may negatively affect VB12 level, indirectly, by reducing 25(OH)D level in middle aged women. | URI: | https://open.uns.ac.rs/handle/123456789/1695 | ISSN: | 264806 | DOI: | 10.23736/S0026-4806.17.05447-7 |
Appears in Collections: | MDF Publikacije/Publications |
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