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https://open.uns.ac.rs/handle/123456789/1636
Title: | Inadequate Production of H2 by Gut Microbiota and Parkinson Disease | Authors: | Ostojić, Sergej | Keywords: | dysbiosis;gut;molecular hydrogen;Parkinson disease | Issue Date: | May-2018 | Journal: | Trends in Endocrinology and Metabolism | Abstract: | Dysbiosis of the gut flora accompanies Parkinson disease (PD), yet no specific cause–effect link has been identified so far. The gut microbiota produce molecular hydrogen (H2), a ubiquitous molecule recently recognized as a biologically active gas with antioxidant, antiapoptotic, anti-inflammatory, cytoprotective, and signaling properties. Here, we discuss an idea that an impaired production of endogenous H2 by intestinal microbiota might play a role in PD pathogenesis, with supplemental H2 debated as a possible therapy for this progressive neurodegenerative disease. | URI: | https://open.uns.ac.rs/handle/123456789/1636 | ISSN: | 1043-2760 | DOI: | 10.1016/j.tem.2018.02.006 |
Appears in Collections: | FSFV Publikacije/Publications |
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