Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/16295
Title: | Novel nano-encapsulation of probucol in microgels: Scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses | Authors: | Armin Mooranian Nassim Zamani Mikov, Momir Goločorbin-Kon, Svetlana Stojanović, Goran Frank Arfuso Hani Al-Salami |
Keywords: | Probucol;Microencapsulation;Chenodeoxycholic acid;Oxidative stress;Topographic analysis;Diabetes | Issue Date: | 18-Sep-2018 | Project: | MEDLEM | Journal: | Artificial Cells, Nanomedicine, and Biotechnology | Abstract: | Smart polymers such as Eudragit (ED) have shown potential applications in oral drug delivery and targeted release. Probucol (PB) is a lipophilic drug used for hypercholesterolemia and possesses desirable antidiabetic effects such as antioxidant and cell protective effects. PB is highly hydrophobic and has poor bioavailability with significant inter- and intra-patient absorption, limiting its clinical applications in diabetes. This study aimed to design and analyse new PB-ED formulations with or without the absorption-enhancer chenodeoxycholic acid (CDCA). Sodium alginate-based microcapsules containing three different Eudragit polymers (NM30D, RL30D, and RS30D) were investigated with or without CDCA via scanning electron microscopy, energy dispersive X-ray spectroscopy, confocal microscopy, osmotic stability, mechanical properties, buoyancy, release profiles (pH 7.4), thermal stability, and antioxidant effects. Microcapsules’ effects on pancreatic β-cell survival, function, inflammatory profile, and PB cellular uptake were analyzed. All microcapsules showed uniform morphology and surface topography with CDCA being distributed evenly throughout the microcapsules. Osmotic stability was significantly improved in PB-NM30D and PB-RL30D microcapsules (p<0.01 and p<0.05 respectively), and PB-NM30D microcapsules displayed low buoyancy (p<0.01). CDCA improved PB-NM30D effects on pancreatic β-cell function and bioenergetics, which suggests potential application of PB-NM30D-CDCA in PB delivery and diabetes treatment | URI: | https://open.uns.ac.rs/handle/123456789/16295 | ISSN: | 2169-1401 | DOI: | 10.1080/21691401.2018.1511571 |
Appears in Collections: | MDF Publikacije/Publications |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Novel nanoencapsulation.pdf | 1.18 MB | Adobe PDF | View/Open |
Page view(s)
48
Last Week
8
8
Last month
0
0
checked on May 3, 2024
Download(s)
9
checked on May 3, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.