Configurations in unsymmetrically N-methyl-N-cycloalkyl substituted 2-phenylacetamides

Abstract

As a part of a study on the structural and vibrational properties of some new various N-alkyl-N-substituted 2-phenylacetamides, the infrared and 1H n.m.r. spectra were obtained and interpreted. The synthesis of a various N-methyl-N-substituted 2-phenylacetamides of the general formula PhCH2CON(CH3)R, in which the substituent group is (C3-C7) cycloalkyl group, were performed. The 1H n.m.r. spectra of these unsymmetrically N,N-disubstituted amides have been studied and the peaks have been assigned in each case to two possible conformational isomers, arising from the lack of free rotation about the C(O)N bond. These results are in accordance with our previous investigation of the structures of N-substituted 2-phenylacetamides. © 1988.