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https://open.uns.ac.rs/handle/123456789/14466
Nаziv: | Modulating activity of fullerol C <inf>60</inf> (OH) <inf>22</inf> on doxorubicin-induced cytotoxicity | Аutоri: | Bogdanović G. Kojić, Vesna Đorđević, Aleksandar Čanadanović-Brunet, Jasna Vojinović-Miloradov M. Baltić V. |
Dаtum izdаvаnjа: | 1-јан-2004 | Čаsоpis: | Toxicology in Vitro | Sažetak: | Paper presents the effects of the newly synthesized fullerol C 60 (OH) 22 on the growth of tumor cells in vitro and its modulating activity on doxorubicin (DOX)-induced cytotoxicity in human breast cancer cell lines. Cell growth inhibition was evaluated by tetrazolium colorimetric WST1 assay. Electron spin resonance (ESR) "trapping" method was used to investigate OH-radical scavenger activity of fullerol during Fenton's reaction. At a range of nanomolar concentrations fullerol induced cell growth inhibition, which was cell line, dose and time dependent. Fullerol also strongly suppressed DOX-induced cytotoxicity at all concentrations regardless the time of fullerol addition. Proanthocyanidins added as single agent to MCF-7 cell culture for 48 h induced low growth inhibition but in combination with DOX strongly decreased DOX cytotoxicity. Fullerol was found to be a potent hydroxyl radical scavenger: the relative intensity of ESR signals of DMPO-hydroxyl radical (DMPO-OH) spin adduct decreased by 88% in the presence of 0.5 μg/ml of fullerol. The obtained results suggest that antiproliferative effect of the fullerol and its protective effect on DOX-induced cytotoxicity might be mediated through hydroxyl-radical scavenger activity of C 60 (OH) 22 . © 2004 Elsevier Ltd. All rights reserved. | URI: | https://open.uns.ac.rs/handle/123456789/14466 | ISSN: | 08872333 | DOI: | 10.1016/j.tiv.2004.02.010 |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications TF Publikacije/Publications |
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