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https://open.uns.ac.rs/handle/123456789/13984
Title: | The effect of aluminium chloride upon the transition of drugs through the blood-brain barrier into the central nervous system | Authors: | Jakovljević V. Banić B. Radunović A. |
Issue Date: | 1-Jul-1991 | Journal: | European Journal of Drug Metabolism and Pharmacokinetics | Abstract: | In order to determine the effect of Al3+ upon the transition of drugs through the blood-brain barrier into the central nervous system we examined its effect upon a drug that dissociates as a cation (quinidine) and drugs that dissociate as anions (acetylsalicylic acid and pentobarbital). The entry and exit of quinidine into and out of the brain in mice pre-treated with AICI3 was inhibited. Al3+ did not compete with acetylsalicylic acid for the penetration through the blood-brain barrier but did slow down its elimination from the brain. Brain kinetics of the examined drugs showed good correlation with their central pharmacodynamic effects. © 1991 Springer-Verlag. | URI: | https://open.uns.ac.rs/handle/123456789/13984 | ISSN: | 03787966 | DOI: | 10.1007/BF03189955 |
Appears in Collections: | MDF Publikacije/Publications |
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