Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/13269
Nаziv: | The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death | Аutоri: | Grdović, Nevena Dinić, Svetlana Arambašić, Jelena Mihailović, Mirjana Uskoković, Aleksandra Marković, Jelena Poznanović, Goran Vidović, Senka Zeković, Zoran Mujić, Aida Mujić, Ibrahim Vidaković, Melita |
Dаtum izdаvаnjа: | 14-окт-2012 | Izdаvаč: | Cambridge University Press | Čаsоpis: | British Journal of Nutrition | Sažetak: | Pancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death. © 2011 The Authors. | URI: | https://open.uns.ac.rs/handle/123456789/13269 | ISSN: | 00071145 | DOI: | 10.1017/S0007114511006702 |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications TF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
27
prоvеrеnо 03.05.2024.
Prеglеd/i stаnicа
66
Prоtеklа nеdеljа
9
9
Prоtеkli mеsеc
4
4
prоvеrеnо 03.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.