Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке:
https://open.uns.ac.rs/handle/123456789/12862
Назив: | Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro | Аутори: | Jukić, Marijana Cvetanović, Aleksandra Mišković Špoljarić, Katarina Savić, Saša Švarc-Gajić, Jaroslava Zeković, Zoran Glavaš-Obrovac, Ljubica |
Датум издавања: | 18-сеп-2019 | Издавач: | Ljubljana: Slovenian Chemical Society | Часопис: | Acta Chimica Slovenica | Сажетак: | © 2019 Slovensko Kemijsko Drustvo. All rights reserved. In the frame of this paper, the enzyme-assisted hydrolysis coupled with ultrasound and Soxhlet extraction was applied in order to get extracts of chamomile ligulate flowers (CLF). Obtained extracts were characterized in terms to their apigenin and apigenin glucoside composition, as well as antiproliferative potential against tumour cells. Antioxidant activity was determined by two different assays based on different mechanisms showing that autofermented extracts have higher reduction potential. Autofermented extracts prepared by ultrasound and Soxhlet extraction had a stronger impact on the treated carcinoma (HeLa and NCI-H358) and leukemia (K562) cells’ growth reduction in comparison to the native extracts, 30–35% greater inhibition at the lowest concentration (0.01 mg/mL), in two observed time points (48 and 72 h). Leukemia cells are more sensitive to all tested extracts. The autofermented CLF extracts with highest antiproliferative efficacy induced morphological changes and apoptosis in the HeLa cells. Obtained results clearly showed that the combination of enzymatic hydrolysis with cavitation phenomenon results in extracts with higher apigenin content and increased biological potential. | URI: | https://open.uns.ac.rs/handle/123456789/12862 | ISSN: | 13180207 | DOI: | 10.17344/acsi.2018.4782 |
Налази се у колекцијама: | TF Publikacije/Publications |
Приказати целокупан запис ставки
SCOPUSTM
Навођења
1
проверено 10.05.2024.
Преглед/и станица
44
Протекла недеља
8
8
Протекли месец
2
2
проверено 10.05.2024.
Google ScholarTM
Проверите
Алт метрика
Ставке на DSpace-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.