Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/12627
Title: | Interaction of alcoholic extracts of hops with cocaine and paracetamol in mice | Authors: | Olga Horvat Aleksandar Rašković Vida Jakovljević Jan Sabo Janoš Berenji |
Keywords: | Alcoholic hop extracts;interaction with cocaine;interaction with paracetamol | Issue Date: | 1-Jan-2007 | Journal: | European Journal of Drug Metabolism and Pharmacokinetics | Abstract: | This work describes a study of the interaction in the mouse model of alcoholic extracts of hops of Magnum, Aroma and wild genotypes with drugs that have excitatory effect on the cerebral cortex (cocaine) and analgesic action (paracetamol). Hop drying and preparation of the extracts were carried out according to standard pharmacological procedures for preparing total alcoholic extracts of dry herbs, consisting of one part of dry drug and two parts of 70% alcohol. The mice received four doses i.p. of 0.5% aqueous solutions of the above-mentioned extracts (10 ml/kg) 24, 16, 4 and 0.5 h prior to receiving cocaine (25 mg/kg) or paracetamol (80 mg/kg). The parameter investigated was the change in spontaneous motility of mice after combined treatment with the extracts and cocaine/paracetamol compared to control animals that received the same dose of the drug after treatment with physiological solution. Only the ethanolic extract of Magnum hops increased the spontaneous motility of mice, while none of the extracts showed analgesic action as measured by the hot-plate method. In the interaction with cocaine, the extract of Magnum hops suppressed almost completely the action of cocaine compared to controls. Extracts of the other hops also decreased the cocaine-induced locomotor activity of mice, but to a lesser extent. Hop extracts exhibited a significant pharmacological interaction with paracetamol, with the most pronounced increase in analgesic action being found for the ethanolic extract of Aroma hops and the tert-butanolic extract of wild hops. | URI: | https://open.uns.ac.rs/handle/123456789/12627 | ISSN: | 3787966 | DOI: | 10.1007/BF03190988 |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
6
checked on May 10, 2024
Page view(s)
34
Last Week
11
11
Last month
6
6
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.