Antimicrobial investigations of copper(II) complexes with some 1-benzylbenzimidazole derivatives

Abstract

In the paper the antimicrobial activity of copper(II) complexes with two series of benzimidazoles was investigated. The first one was based on 1-benzyl-2-aminobenzimidazole, and the second one contained 1-benzyl-2-amino-5, 6-dimethylbenzimidazole. Antibacterial activities of the complexes were evaluated in vitro against three gram-positive bacterial strains (Bacillus cereus, Staphylococcus aureus, and Sarcina lutea) and one gram-negative isolate (Pseudomonas aeruginosa). All the investigated compounds displayed antimicrobial activity against very persistent microorganisms, whilst the inhibitory activity is upper against gram-positive than gram-negative bacteria. Minimum inhibitory concentration (MIC) was determined for all the complexes. The effect of ligand and complex structure on the antimicrobial activity is discussed.