Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/11835
Title: | Mixed micelles of 7,12-dioxolithocholic acid and selected hydrophobic bile acids: Interaction parameter, partition coefficient of nitrazepam and mixed micelles haemolytic potential | Authors: | Mihalj Poša Vesna Tepavčević |
Keywords: | Bile acids;Mixed micelle;Oxo derivatives of bile acids;Critical micellar concentration;Haemolytic potential | Issue Date: | 1-Sep-2011 | Journal: | Colloids and Surfaces B: Biointerfaces | Abstract: | The formation of mixed micelles built of 7,12-dioxolithocholic and the following hydrophobic bile acids was examined by conductometric method: cholic (C), deoxycholic (D), chenodeoxycholic (CD), 12-oxolithocholic (12-oxoL), 7-oxolithocholic (7-oxoL), ursodeoxycholic (UD) and hiodeoxycholic (HD). Interaction parameter (β) in the studied binary mixed micelles had negative value, suggesting synergism between micelle building units. Based on β value, the hydrophobic bile acids formed two groups: group I (C, D and CD) and group II (12-oxoL, 7-oxoL, UD and HD). Bile acids from group II had more negative β values than bile acids from group I. Also, bile acids from group II formed intermolecular hydrogen bonds in aggregates with both smaller (2) and higher (4) aggregation numbers, according to the analysis of their stereochemical (conformational) structures and possible structures of mixed micelles built of these bile acids and 7,12-dioxolithocholic acid.Haemolytic potential and partition coefficient of nitrazepam were higher in mixed micelles built of the more hydrophobic bile acids (C, D, CD) and 7,12-dioxolithocholic acid than in micelles built only of 7,12-dioxolithocholic acid. On the other hand, these mixed micelles still had lower values of haemolytic potential than micelles built of C, D or CD. The mixed micelles that included bile acids: 12-oxoL, 7-oxoL, UD or HD did not significantly differ from the micelles of 7,12-dioxolithocholic acid, observing the values of their haemolytic potential. © 2011 Elsevier B.V. | URI: | https://open.uns.ac.rs/handle/123456789/11835 | ISSN: | 9277765 | DOI: | 10.1016/j.colsurfb.2011.04.008 |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
17
checked on May 10, 2024
Page view(s)
26
Last Week
6
6
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.