Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10909
Title: | Influence of fullerenol C60(OH)24 on enzime status in serum of rats after single dose administration of doxorubicine | Authors: | Govedarica, Biljana Djordjevic-Milic V. Radic N. Srđenović, Branislava Đorđević, Aleksandar |
Issue Date: | 1-Dec-2008 | Journal: | Hemijska Industrija | Abstract: | The antracycline antibiotics have one of the widest areas of use in oncology. The most investigated mechanisms of their antineoplastic activity include: interactions of these antibiotics with DNA, inhibition of topoisomerase II and production of free radicals. However, the side effects of doxorubicin, especially cardiotoxicity, are the limiting factor of its use in cancer therapy. The aim of this research was to investigate the influence of fullerenol C 60(OH)24 as a cytoprotector in single doze administration of doxorubicin on the activity of enzymes in serum (CK, AST, ALT, LDH and α-HBDH) in rats in in vivo system. Activity of enzymes (CK, LDH, HBDH, AST, and ALT) in serume was measured with standard comercial methods. The results of analysis of the samples treated with the combination of fullerenol and doxorubicin show no difference in enzyme activity in comparison with the control group. The results indicate the possibility of using fullerenol as a protector in the therapy with doxorubicin in malign neoplasm. | URI: | https://open.uns.ac.rs/handle/123456789/10909 | ISSN: | 0367598X | DOI: | 10.2298/HEMIND0803191G |
Appears in Collections: | Naučne i umetničke publikacije |
Show full item record
SCOPUSTM
Citations
1
checked on May 10, 2024
Page view(s)
12
Last Week
12
12
Last month
0
0
checked on May 3, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.