Influence of isoproterenol on net potassium uptake in whole pigeon erythrocytes in vitro

Abstract

Isoproterenol increases net uptake of potassium in whole pigeon erythrocytes in vitro; effect of 10-5 M isoproterenol is blocked by 10-4 M propranolol. Pentifylline, a potent inhibitor of cAMP-phosphodiesterase, significantly amplifies effect of isoproterenol, indicating that isoproterenol-effect is mediated by cAMP. cAMP alone has no direct influence on net potassium uptake, while dibuturyl-cAMP has a very weak effect. Isoproterenol-effects are also mediated by the cell membrane protein-phosphorylation. © 1981.