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https://open.uns.ac.rs/handle/123456789/102
Title: | Self-association of sodium isoursodeoxycholate and sodium isohenodeoxycholate in water | Authors: | Vesna Tepavčević Ana Pilipović Zita Farkaš Agatić Kosta Popović Mihalj Poša |
Keywords: | Hydrophobic effect;Steroid skeleton;Hydration;Isothermal titration calorimetry;Aggregation number;Critical micelle concentration | Issue Date: | 1-Sep-2019 | Journal: | Chemistry and Physics of Lipids | Abstract: | © 2019 Elsevier B.V. Bile salts (BS) form hydrophobic Small's primary micelles at concentrations above the critical micelle concentration (CMC), while at concentrations above 3CMC they form secondary micelles (by the association of primary micelles via H-bonds). In this paper the self-associations of the anions of isohenodeoxycholic acid (3-epimer of henodeoxycholic acid, ICD) and the anions of isoursodeoxycholic acid (3-epimer of ursodeoxycholic acid, IUD) are examined, since the thermodynamic parameters of their self-association have not yet been published. Forming of IUD aggregates with two or three building units is slightly more favorable via α sides of steroid skeletons, regarding hydrophobicity, while regarding steric repulsive interactions it is more favorable to associate via β sides. Due to this, IUD in the vicinity of the CMC can form primary micelles by association of IUD particles both from the convex side and from the concave side of the steroid ring system. Therefore, IUD is significantly more prone to initial micellization than bile salt derivatives whose steroidal skeletons contain equatorially oriented OH groups. | URI: | https://open.uns.ac.rs/handle/123456789/102 | ISSN: | 93084 | DOI: | 10.1016/j.chemphyslip.2019.05.003 |
Appears in Collections: | MDF Publikacije/Publications |
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