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https://open.uns.ac.rs/handle/123456789/9768| Title: | Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids | Authors: | Joksović M. Bogdanović G. Kojić, Vesna Mesaroš-Sečenji (Mészáros Szécsényi), Katalin Leovac V. Jakimov D. Trifunov, S. Marković V. Joksović L. |
Issue Date: | 1-Jul-2010 | Journal: | Journal of Heterocyclic Chemistry | Abstract: | (Chemical Equation Presented) New N-[(1,3-diphenylpyrazol-4-yl)methyl]a- amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. © 2010 HeteroCorporation. | URI: | https://open.uns.ac.rs/handle/123456789/9768 | ISSN: | 0022152X | DOI: | 10.1002/jhet.400 |
| Appears in Collections: | PMF Publikacije/Publications |
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