Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9664
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Nebojša Pavlović | en_US |
dc.contributor.author | Bojan Stanimirov | en_US |
dc.contributor.author | Maja Đanić | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Karmen Stankov | en_US |
dc.contributor.author | Hani Al-Salami | en_US |
dc.date.accessioned | 2020-02-05T20:45:42Z | - |
dc.date.available | 2020-02-05T20:45:42Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 3787966 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/9664 | - |
dc.description.abstract | The continuously increasing incidence of diabetes worldwide has attracted the attention of the scientific community and driven the development of a novel class of antidiabetic drugs that can be safely and effectively used in diabetic patients. Of particular interest in this context are complications associated with diabetes, such as renal impairment, which is the main cause of high cardiovascular morbidity and mortality in diabetic patients. Intensive control of glucose levels and other risk factors associated with diabetes and metabolic syndrome provides the foundations for both preventing and treating diabetic nephropathy. Dipeptidyl peptidase-4 (DPP-4) inhibitors represent a highly promising novel class of oral agents used in the treatment of type 2 diabetes mellitus that may be successfully combined with currently available antidiabetic therapeutics in order to achieve blood glucose goals. Beyond glycemic control, emerging evidence suggests that DPP-4 inhibitors may have desirable off-target effects, including renoprotection. All type 2 diabetes mellitus patients with impaired renal function require dose adjustment of any DPP-4 inhibitor administered except for linagliptin, for which renal excretion is a minor elimination pathway. Thus, linagliptin is the drug most frequently chosen to treat type 2 diabetes mellitus patients with renal failure. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European journal of drug metabolism and pharmacokinetics | en_US |
dc.subject | Renoprotection | en_US |
dc.subject | Pharmacokinetics | en_US |
dc.subject | Diabetes mellitus type 2 | en_US |
dc.subject | Renal failure | en_US |
dc.subject | Diabetic nephropathy | en_US |
dc.title | DPP-4 Inhibitors: Renoprotective Potential and Pharmacokinetics in Type 2 Diabetes Mellitus Patients with Renal Impairment | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.1007/s13318-019-00570-y | - |
dc.identifier.pmid | 31385198 | - |
dc.identifier.scopus | 2-s2.0-85070217911 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85070217911 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 14 | en_US |
dc.relation.firstpage | 1 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 45 | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Katedra za farmaciju | - |
crisitem.author.dept | Katedra za biohemiju | - |
crisitem.author.dept | Katedra za farmakologiju i toksikologiju | - |
crisitem.author.dept | Katedra za biohemiju | - |
crisitem.author.orcid | 0000-0002-9444-5830 | - |
crisitem.author.orcid | 0000-0002-0708-3182 | - |
crisitem.author.orcid | 0000-0002-7785-0666 | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
crisitem.author.orcid | 0000-0002-3888-3473 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
Files in This Item:
File | Size | Format | |
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DPP-4 Inhibitors Renoprotective Potential and Pharmacokinetics in Type 2 Diabetes Mellitus Patients with Renal Impairment.pdf | 792.96 kB | Adobe PDF | View/Open |
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