Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9489
DC Field | Value | Language |
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dc.contributor.author | Stojadinović, Alexander | en_US |
dc.contributor.author | Nissan A. | en_US |
dc.contributor.author | Wainberg Z. | en_US |
dc.contributor.author | Shen P. | en_US |
dc.contributor.author | McCarter M. | en_US |
dc.contributor.author | Mlađan Protić | en_US |
dc.contributor.author | Howard R. | en_US |
dc.contributor.author | Steele S. | en_US |
dc.contributor.author | Peoples G. | en_US |
dc.contributor.author | Bilchik A. | en_US |
dc.date.accessioned | 2019-09-30T09:16:18Z | - |
dc.date.available | 2019-09-30T09:16:18Z | - |
dc.date.issued | 2012-12-01 | - |
dc.identifier.issn | 10689265 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/9489 | - |
dc.description.abstract | Background. Lymph node yield (LNY) and accuracy of nodal assessment are critical to staging and treatment planning in colon cancer (CC). A nationally agreed upon 12-node minimum is a quality standard in CC. The impact of this quality measure onLNY and impact on therapeutic decisions are evaluated in two international, multi-center, prospective trials comprising a well-characterized cohort assembled over 8 years (2001-2009) with long-term follow-up. Hypothesis. Quality adherence through increased LNY improves staging accuracy and impacts adjuvant therapy decisions. Methods. Retrospective analysis of prospective data to assess time-dependent LNY, the dependent variable in multivariate linear regression analysis adjusted for age, gender, body-mass-index (BMI), tumor size/stage/grade, anatomic location and surgery date. Results. Two-hundred-forty-five patients with non-meta-static CC, median age 70 years, BMI 26 kg/m2, tumor size 4.0 cm, and LNY 17 nodes were studied. Seventy-two percent had T3 (70 %)/T4 (2 %) tumors. Adherence to the 12-node minimum was 70 %(2001-2002), 81 % (2003-2004), 90 % (2005-2006), 94 % (2007-2008). LNY significantly increased over time (Median LNY: 2001- 2004 = 15 vs. 2005-2008 = 17; P<0.001) on multivari-ate analysis controlling for tumor size (P < 0.001), and right-sided tumor location (P< 0.001). Adjuvant therapy administration and indication for chemotherapy according to LNY (<12 vs. 12 ? LNs = 33 % vs. 39 %; P = 0.48) and time period (2001-2004 vs. 2005-2008 = 39 % vs. 37 %; P = 0.89) remained unchanged. Conclusions. Despite the independent predictors of nodal yield (tumor location and size), year of study still had a significant impact on nodal yield. Despite increased quality adherence and LNY over time, there appears to be a delayed impact on adjuvant therapy decisions once quality standard adherence takes effect. © 2012 Society of Surgical Oncology. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Annals of Surgical Oncology | en_US |
dc.subject | colon cancer | en_US |
dc.subject | staging | en_US |
dc.subject | lymph node yield | en_US |
dc.title | Time-dependent trends in lymph node yield and impact on adjuvant therapy decisions in colon cancer surgery: An international multi-institutional study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1245/s10434-012-2501-5 | - |
dc.identifier.pmid | 19 | - |
dc.identifier.scopus | 2-s2.0-84876480366 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84876480366 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 4185 | en_US |
dc.relation.firstpage | 4178 | en_US |
dc.relation.issue | 13 | en_US |
dc.relation.volume | 19 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za hirurgiju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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