Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9392
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Maja Đurendić-Brenesel | en_US |
dc.contributor.author | Vladimir Pilija | en_US |
dc.contributor.author | Neda Mimica-Dukić | en_US |
dc.contributor.author | Branislav Budakov | en_US |
dc.contributor.author | Stanko Cvjetićanin | en_US |
dc.date.accessioned | 2019-09-30T09:15:36Z | - |
dc.date.available | 2019-09-30T09:15:36Z | - |
dc.date.issued | 2012-12-01 | - |
dc.identifier.issn | 13376853 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/9392 | - |
dc.description.abstract | The present study examined regional distribution of opiate alkaloids from seized heroin in brain regions of experimental animals in order to select parts with the highest content of opiates. Their analysis should contribute to resolve causes of death due to heroin intake. The tests were performed at different time periods (5, 15, 45 and 120 min) after male and female Wistar rats were treated with seized heroin. Opiate alkaloids (codeine, morphine, acetylcodeine, 6-acetylmorphine and 3,6-diacetylmorphine) were quantitatively determined in brain regions known for their high concentration of μ-opiate receptors: cortex, brainstem, amygdala and basal ganglia, by using gas chromatography-mass spectrometry (GC-MS). The highest content of opiate alkaloids in the brain tissue of female animals was found 15 min and in male animals 45 min after treatment. The highest content of opiates was determined in the basal ganglia of the animals of both genders, indicating that this part of brain tissue presents a reliable sample for identifying and assessing contents of opiates after heroin intake. Copyright © 2012 SETOX & IEPT, SASc. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Interdisciplinary Toxicology | en_US |
dc.subject | seized heroin | en_US |
dc.subject | rats | en_US |
dc.subject | opiates’ distribution | en_US |
dc.subject | basal ganglia | en_US |
dc.subject | GC-MS | en_US |
dc.title | Distribution of opiate alkaloids in brain tissue of experimental animals | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.2478/v10102-012-0029-y | - |
dc.identifier.scopus | 2-s2.0-84876538298 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84876538298 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 178 | en_US |
dc.relation.firstpage | 173 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 5 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Katedra za sudsku medicinu | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Кatedra za prirodne nauke i menadžment u obrazovanju | - |
crisitem.author.orcid | 0000-0002-8294-6881 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Pedagoški fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
SCOPUSTM
Citations
5
checked on Nov 20, 2023
Page view(s)
34
Last Week
4
4
Last month
10
10
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.