Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/932
DC Field | Value | Language |
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dc.contributor.author | Cvetanović, Aleksandra | en_US |
dc.contributor.author | Zeković, Zoran | en_US |
dc.contributor.author | Zengin, Gokhan | en_US |
dc.contributor.author | Mašković, Pavle | en_US |
dc.contributor.author | Petronijević, Mirjana | en_US |
dc.contributor.author | Radojković, Marija | en_US |
dc.date.accessioned | 2019-09-23T10:12:15Z | - |
dc.date.available | 2019-09-23T10:12:15Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 02546299 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/932 | - |
dc.description.abstract | © 2018 South African Association of Botanists In the frame of the present paper the enzymatic transformation of apigenin-glucosides into free aglycone was achieved by autofermentation of chamomile ligulate flowers (CLF). Antioxidant properties of the autofermented CLF (A-CLF) extract were evaluated by their radical scavenging activity against hydroxyl radicals and inhibition of lipid peroxidation. Obtained results showed that A-CLF extract in a concentration of 0.84 mg/mL was able to inhibit 50% of hydroxyl radicals, while IC 50 value in the case of inhibition of lipid peroxidation was 5.21 mg/mL. Antimicrobial activity was done by measuring minimal inhibitory concentration (MIC) values for eight microbial strains. Obtained MIC values (9.75–156.25 μg/mL) confirmed high antibacterial and antifungal activities of the extract. Cytotoxic activity was done by using three histological different cell lines: Hep2C; RD and L2OB. Obtained IC 50 values for these cell lines were: 28.72; 17.31 and 10.92, respectively. Furthermore, in vitro investigation of the A-CLF ability to inhibit selected enzymes (α-amylase, α-glucosidase, tyrosinase) was done as well. Determined activities against α-amylase and α-glucosidase were 0.94 and 3.24 mmol ACAE/g, respectively. Further, measured activity against tyrosinase was 0.69 mg KAEs/g indicating high enzyme-inhibitory activity of examined sample. Results demonstrated that A-CLF extracts showed considerable pharmacological activity. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | South African Journal of Botany | en_US |
dc.title | Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.sajb.2018.01.003 | - |
dc.identifier.scopus | 2-s2.0-85041173166 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85041173166 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 118 | en_US |
dc.relation.firstpage | 112 | en_US |
dc.relation.volume | 120 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za biotehnologiju | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za biotehnologiju | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za opšte inženjerske discipline | - |
crisitem.author.dept | Tehnološki fakultet, Katedra za hemijsko inženjerstvo | - |
crisitem.author.orcid | 0000-0001-5621-1788 | - |
crisitem.author.orcid | 0000-0002-5432-7071 | - |
crisitem.author.orcid | 0000-0002-8000-3740 | - |
crisitem.author.orcid | 0000-0002-1858-8979 | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
crisitem.author.parentorg | Tehnološki fakultet | - |
Appears in Collections: | TF Publikacije/Publications |
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