Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/9056
Title: Application of QSAR models in analysis of antibacterial activity of some benzimidazole derivatives against Sarcina lutea
Authors: Podunavac-Kuzmanović, Sanja 
Cvetković, Dragoljub 
Jevrić, Lidija 
Uzelac, Nataša
Issue Date: 20-Mar-2013
Publisher: Belgrade: Association of the Chemical Engineers of Serbia
Journal: Hemijska Industrija
Abstract: In the present study, a quantitative structure activity relationship (QSAR) has been carried out on a series of 2-methyl and 2-aminobenzimidazole derivatives to identify the lipophilicity requirements for their inhibitory activity against bacteria Sarcina lutea. The tested compounds displayed in vitro antibacterial activity and minimum inhibitory concentration (MIC) was determined for all compounds. The partition coefficients of the studied compounds were measured by the shake flask method (log P) and by theoretical calculation (Clog P). The relationships between lipophilicity descriptors and antibacterial activities were investigated and the mathematical models have been developed as a calibration models for predicting the inhibitory activity of this class of compounds. The models were validated by the leave-one-out (LOO) technique as well as by the calculation of statistical parameters for the established models. Therefore, QSAR analysis reveals that the lipophilicity descriptor governs the inhibitory activity of benzimidazoles studied against Sarcina lutea.
URI: https://open.uns.ac.rs/handle/123456789/9056
ISSN: 0367598X
DOI: 10.2298/HEMIND120313054P
Appears in Collections:TF Publikacije/Publications

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