Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/9002
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dc.contributor.authorMilošević, Natašaen_US
dc.contributor.authorDimova V.en_US
dc.contributor.authorPerišić-Janjić N.en_US
dc.date.accessioned2019-09-30T09:12:46Z-
dc.date.available2019-09-30T09:12:46Z-
dc.date.issued2013-04-11-
dc.identifier.issn09280987en_US
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/9002-
dc.description.abstractReversed-phase thin-layer chromatographic (RP TLC) retention constants for a newly designed series benzimidazole/benztriazole with expected biological activity were determined as parameters of their lipophilicity and this series was recognized as congeneric. Pharmacokinetic descriptors of the compounds investigated were calculated in silico with the use of the established drug design software. The bioactivity descriptors, which are assumed to predicted drug absorption, distribution, metabolism, elimination and toxicity (ADMETox) in humans, were correlated with retention constants and good statistical parameters were obtained. Multiple regression analysis which was introduced suggested that the absorption through different epithelial membranes (intestinal, blood-brain or erythrocyte membrane) and distribution process depend on retention constants (as measure of lipophilicty) and total polar surface area and molar weight/volume of the analyte. Finally, the compounds with halogen substituent (compounds A4/A7 and A5/A8 in Table 1), were suggested as the best drug candidates, because of their predicted proper pharmacokinetics and have been proposed for further biological tests. © 2013 Elsevier B.V. All rights reserved.en
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciencesen
dc.titleRP TLC data in correlation studies with in silico pharmacokinetic properties of benzimidazole and benztriazole derivativesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.1016/j.ejps.2013.01.018-
dc.identifier.scopus2-s2.0-84874944418-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84874944418-
dc.description.versionUnknownen_US
dc.relation.lastpage17en
dc.relation.firstpage10en
dc.relation.issue1en
dc.relation.volume49en
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptMedicinski fakultet, Katedra za farmaciju-
crisitem.author.orcid0000-0002-5286-3858-
crisitem.author.parentorgMedicinski fakultet-
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