Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7921
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mirjana Kovač | en_US |
dc.contributor.author | Željko Miković | en_US |
dc.contributor.author | Gorana Mitić | en_US |
dc.contributor.author | Valentina Đorđević | en_US |
dc.contributor.author | Vesna Mandić | en_US |
dc.contributor.author | Ljiljana Rakičević | en_US |
dc.contributor.author | Dragica Radojković | en_US |
dc.date.accessioned | 2019-09-30T09:05:20Z | - |
dc.date.available | 2019-09-30T09:05:20Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 10760296 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7921 | - |
dc.description.abstract | The study was conducted to evaluate the effect of anticoagulant therapy in women with thrombophilia and to detect the possible differences among carriers of mutations (factor V [FV] Leiden and FIIG20210) and those with natural anticoagulant deficiency. The 4-year prospective investigation included 85 pregnant women, with a history of recurrent fetal loss (RFL). They were treated with prophylactic doses of low-molecular-weight heparin (nadroparin) starting from 6 to 8 weeks of gestation. Pregnancy outcomes were evaluated based on the thrombophilia type. Carriers of thrombophilic mutations had a live birth rate of 93%, compared to 41.6% for women with natural anticoagulant deficiencies. Significant differences between the groups were also observed for intrauterine fetal death, intrauterine growth restriction, and postpartum thrombosis. The optimal therapy for women with natural anticoagulant deficiency and RFL remains unclear and future prospective study with a large number of patients is required to determine the best treatment for these severe thrombophilic conditions. © The Author(s) 2013. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clinical and Applied Thrombosis/Hemostasis | en_US |
dc.subject | inherited thrombophilia | en_US |
dc.subject | low-molecular-weight heparin | en_US |
dc.subject | pregnancy outcome | en_US |
dc.title | Does anticoagulant therapy improve pregnancy outcome equally, regardless of specific thrombophilia type? | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1177/1076029612468940 | - |
dc.identifier.pmid | 20 | - |
dc.identifier.scopus | 2-s2.0-84893439242 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84893439242 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 189 | en_US |
dc.relation.firstpage | 184 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 20 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patološku fiziologiju i laboratorijsku medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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