Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7911
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aleksandar Savić | en_US |
dc.contributor.author | Dragomir Marisavljević | en_US |
dc.contributor.author | Vanja Kvrgić | en_US |
dc.contributor.author | Nataša Stanisavljević | en_US |
dc.date.accessioned | 2019-09-30T09:05:15Z | - |
dc.date.available | 2019-09-30T09:05:15Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 15792 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7911 | - |
dc.description.abstract | The objective of this study is to externally validate the recently published Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndrome (MDS) and compare it with the International Prognostic Scoring System (IPSS). We conducted a retrospective study of 173 adult MDS patients who had not received disease-altering treatment. Using the Cox hazard method, we found the IPSS-R to be a significant predictor of survival (p < 0.001, hazard ratio, HR = 1.82, 95% confidence interval, CI 1.57-2.12) and time to acute myeloid leukemia (AML; p < 0.001, HR = 2.05, 95% CI 1.55-2.70). The IPSS-R has greater prognostic power for survival and time to AML compared with the IPSS, given higher Somers' D values (0.41 vs. 0.39 and 0.55 vs. 0.53, respectively). Using the log-rank test, we found a significant difference when comparing IPSS-R groups (p < 0.02), with the exception of the high-risk versus very high-risk group comparison. The IPSS-R reclassified low-risk and intermediate-1 IPSS groups into four groups (log-rank, p < 0.001) and intermediate-2 and high-risk IPSS groups into three groups (log-rank, p < 0.04, excluding high-risk vs. very high-risk comparison). We conclude that the IPSS-R has significant prognostic utility for MDS patients. © 2013 S. Karger AG, Basel. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Acta Haematologica | en_US |
dc.subject | Prognostic Scoring System | en_US |
dc.subject | myelodysplastic syndrome | en_US |
dc.title | Validation of the revised international prognostic scoring system for patients with myelodysplastic syndromes | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1159/000354840 | - |
dc.identifier.pmid | 131 | - |
dc.identifier.scopus | 2-s2.0-84901348957 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84901348957 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 238 | en_US |
dc.relation.firstpage | 231 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 131 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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