Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7824
DC Field | Value | Language |
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dc.contributor.author | Mooranian A. | en_US |
dc.contributor.author | Negrulj R. | en_US |
dc.contributor.author | Mathavan S. | en_US |
dc.contributor.author | Martinez J. | en_US |
dc.contributor.author | Sciarretta J. | en_US |
dc.contributor.author | Chen-Tan N. | en_US |
dc.contributor.author | Mukkur T. | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Mladena Lalić-Popović | en_US |
dc.contributor.author | Maja Stojancěvić | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Al-Salami H. | en_US |
dc.date.accessioned | 2019-09-30T09:04:39Z | - |
dc.date.available | 2019-09-30T09:04:39Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 18725120 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7824 | - |
dc.description.abstract | Introduction: In previous studies carried out in our laboratory, a bile acid (BA) formulation exerted a hypoglycaemic effect in a rat model of type-1 diabetes (T1D). When the antidiabetic drug gliclazide (G) was added to the bile acid, it augmented the hypoglycaemic effect. In a recent study, we designed a new formulation of gliclazide-cholic acid (G-CA), with good structural properties, excipient compatibility and exhibits pseudoplastic-thixotropic characteristics. The aim of this study is to test the slow release and pH-controlled properties of this new formulation. The aim is also to examine the effect of CA on G release kinetics at various pH values and different temperatures. Method: Microencapsulation was carried out using our Buchi-based microencapsulating systemdeveloped in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) and G-CA-SA (test) at a constant ratio (1:3:30), respectively. Microcapsules were examined for efficiency, size, release kinetics, stability and swelling studies at pH 1.5, pH 3, pH 7.4 and pH 7.8 and temperatures of 20 and 30°C. Results: The new formulation is further optimised by the addition of CA. CA reduced microcapsule swelling of the microcapsules at pH 7.8 and pH 3 at 30°C and pH 3 at 20°C, and, even though microcapsule size remains similar after CA addition, percent G release was enhanced at high pH values (pH 7.4 and pH 7.8, p<0.01). Conclusion: The new formulation exhibits colon-targeted delivery and the addition of CA prolonged G release suggesting its suitability for the sustained and targeted delivery of G and CA to the lower intestine. © The Author(s) 2014. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Pharmaceutical Innovation | en_US |
dc.subject | Artificial-cell microencapsulation | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Bile acid | en_US |
dc.subject | Gliclazide | en_US |
dc.title | Stability and release kinetics of an advanced gliclazide-cholic acid formulation: The Use of artificial-cell microencapsulation in slow release targeted oral delivery of antidiabetics | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1007/s12247-014-9182-5 | - |
dc.identifier.scopus | 2-s2.0-84905722565 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84905722565 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 157 | en_US |
dc.relation.firstpage | 150 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 9 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.orcid | 0000-0001-8354-3868 | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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