Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7427
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Milena Mitrović | en_US |
dc.contributor.author | Đorđe Popović | en_US |
dc.contributor.author | Dragana Tomić Naglić | en_US |
dc.contributor.author | Jovanka Novaković-Paro | en_US |
dc.contributor.author | Tatjana Ilić | en_US |
dc.contributor.author | Branka Kovačev-Zavišić | en_US |
dc.date.accessioned | 2019-09-30T09:01:55Z | - |
dc.date.available | 2019-09-30T09:01:55Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 18951058 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7427 | - |
dc.description.abstract | Aims. Long-term hyperglycemia, characteristic for type 1 diabetes, causes enhanced oxidative stress, chronic inflammation and endothelial dysfunction which are the key events in the development of vascular complications. On the other hand, some data shows that existence of chronic degenerative complications may cause increased inflammatory marker levels in diabetic patients, mainly as a repercussion of malfunctioned endothelial repair process. Our study aims to determinate a degree of inflammation in type 1 diabetes patients and to investigate its relation to development of the chronic microvascular complications. Methods: General information, anthropometric, glucose metabolism, lipid and lipoprotein parameters, levels of C reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were analyzed and screening tests for detection of the chronic microvascular complications were conducted in 76 type 1 diabetes patients. Results: Forty six patients had at least one of the complications. They were older and had longer duration of diabetes (p=0.015; p<0.0001) and higher values of total (p=0.021), LDL-cholesterol (p=0.048) and triglycerides (p=0.002). Levels of CRP (p=0.004) and TNF-α (p=0.048) were higher in patients with chronic microvascular complications in regard to patients without diagnosed microangiopathy. Conclusion: Low grade chronic inflammation is characteristic for type 1 diabetes patients with developed chronic microvascular complications. © 2014 Versita Warsaw and Springer-Verlag. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Central European Journal of Medicine | en_US |
dc.subject | Type 1 diabetes mellitus | en_US |
dc.subject | Diabetes complications | en_US |
dc.subject | Inflammation | en_US |
dc.title | Markers of inflammation and microvascular complications in type 1 diabetes | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.2478/s11536-013-0335-6 | - |
dc.identifier.scopus | 2-s2.0-84907318287 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84907318287 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 753 | en_US |
dc.relation.firstpage | 748 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 9 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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