Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7312
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Romano B. | en_US |
dc.contributor.author | Fasolino I. | en_US |
dc.contributor.author | Pagano E. | en_US |
dc.contributor.author | Capasso R. | en_US |
dc.contributor.author | Pace S. | en_US |
dc.contributor.author | De Rosa G. | en_US |
dc.contributor.author | Milić, Nataša | en_US |
dc.contributor.author | Orlando P. | en_US |
dc.contributor.author | Izzo A. | en_US |
dc.contributor.author | Borrelli F. | en_US |
dc.date.accessioned | 2019-09-30T09:01:04Z | - |
dc.date.available | 2019-09-30T09:01:04Z | - |
dc.date.issued | 2014-03-01 | - |
dc.identifier.issn | 16134125 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7312 | - |
dc.description.abstract | Scope: Colorectal cancer is an important health problem across the world. Here, we investigated the possible antiproliferative/proapoptotic effects of bromelain (from the pineapple stem Ananas comosus L., family Bromeliaceae) in a human colorectal carcinoma cell line and its potential chemopreventive effect in a murine model of colon cancer. Methods and results: Proliferation and apoptosis were evaluated in human colon adenocarcinoma (Caco-2) cells by the 3H-thymidine incorporation assay and caspase 3/7 activity measurement, respectively. Extracellular signal-related kinase (ERK) and Akt expression were evaluated by Western blot analysis, reactive oxygen species production by a fluorimetric method. In vivo, bromelain was evaluated using the azoxymethane murine model of colon carcinogenesis. Bromelain reduced cell proliferation and promoted apoptosis in Caco-2 cells. The effect of bromelain was associated to downregulation of pERK1/2/total, ERK, and pAkt/Akt expression as well as to reduction of reactive oxygen species production. In vivo, bromelain reduced the development of aberrant crypt foci, polyps, and tumors induced by azoxymethane. Conclusion: Bromelain exerts antiproliferative and proapoptotic effects in colorectal carcinoma cells and chemopreventive actions in colon carcinogenesis in vivo. Bromelain-containing foods and/or bromelain itself may represent good candidates for colorectal cancer chemoprevention. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | en |
dc.relation.ispartof | Molecular Nutrition and Food Research | en |
dc.title | The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1002/mnfr.201300345 | - |
dc.identifier.scopus | 2-s2.0-84897619560 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84897619560 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 465 | en |
dc.relation.firstpage | 457 | en |
dc.relation.issue | 3 | en |
dc.relation.volume | 58 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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