Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/6940
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ostojić, Sergej | en_US |
dc.contributor.author | Stojanović , Marko | en_US |
dc.contributor.author | Drid, Patrik | en_US |
dc.contributor.author | Hoffman, Jay R. | en_US |
dc.date.accessioned | 2019-09-30T08:58:33Z | - |
dc.date.available | 2019-09-30T08:58:33Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1436-6207 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/6940 | - |
dc.description.abstract | Purpose Guanidinoacetic acid (GAA) is an intermediate in the biosynthesis of creatine (Cr), yet its use in human nutrition is limited due to a lack of a clear understanding of its’ dose–response effect. Thus, the purpose of this study was to investigate the effect of three different dosages of GAA (1.2, 2.4 and 4.8 g/day) administered for 6 weeks on serum and urinary variables related to GAA metabolism. Methods Forty-eight healthy volunteers participated in the randomized, placebo-controlled, double-blind, repeated measure study. At baseline, after 1, 2, 4 and 6 weeks, participants provided both fasting blood samples and 24-h urine. Results GAA intervention significantly increased serum and urinary GAA, Cr and creatinine as compared to placebo (P < 0.05). Differences were found for serum GAA and Cr responses between the three GAA dosages, with high-dose GAA resulting in a greater increase (P < 0.05) in the plasma concentration of both variables as compared to other GAA dosages. In GAA groups, fasting plasma total homocysteine (T Hcy) increased by 3.5 μmol/L on average at post-administration, yet no dose–response differences were found between trials. Serum B vitamins were not affected by either placebo or GAA intervention (P > 0.05). Conclusion Results indicate that low-to-high dosages of exogenous GAA can increase serum concentrations of Cr and T-Hcy while not depleting the B vitamins pool available for remethylation of homocysteine. Clinical trial registration: ClinicalTrials.gov, identification number NCT01133899. | en_US |
dc.relation.ispartof | European Journal of Nutrition | en_US |
dc.subject | Creatine | en_US |
dc.subject | Creatinine | en_US |
dc.subject | Bioenergetics | en_US |
dc.subject | Homocysteine | en_US |
dc.subject | Supplementation | en_US |
dc.title | Dose–response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1007/s00394-014-0669-0 | - |
dc.identifier.scopus | 2-s2.0-84938936584 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84938936584 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 1643 | en_US |
dc.relation.firstpage | 1637 | en_US |
dc.relation.volume | 53 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Fakultet sporta i fizičkog vaspitanja, Katedra za primenjene sportske nauke | - |
crisitem.author.dept | Fakultet sporta i fizičkog vaspitanja, Katedra za kolektivne sportove | - |
crisitem.author.dept | Fakultet sporta i fizičkog vaspitanja, Katedra za individualne sportove | - |
crisitem.author.orcid | 0000-0002-7270-2541 | - |
crisitem.author.orcid | 0000-0002-6606-7449 | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
crisitem.author.parentorg | Fakultet sporta i fizičkog vaspitanja | - |
Appears in Collections: | FSFV Publikacije/Publications |
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