Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/6827
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dc.contributor.authorDanijela Jojkić Pavkoven_US
dc.contributor.authorMelanija Vislavskien_US
dc.contributor.authorNada Vučkovićen_US
dc.contributor.authorBojana Petrovački Dejanovićen_US
dc.contributor.authorMatilda Djolai (Đolai)en_US
dc.contributor.authorSmiljana Marinkovićen_US
dc.contributor.authorMilena Mitrovićen_US
dc.date.accessioned2019-09-30T08:57:45Z-
dc.date.available2019-09-30T08:57:45Z-
dc.date.issued2014-01-01-
dc.identifier.issn13301403en_US
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/6827-
dc.description.abstractImmaturity of ganglion cells is a rare form of dysganglionosis that belongs to the group of dysmorphic types, characterized by a normal or mildly decreased number of ganglion cells, with the cells and their nuclei being considerably smaller in size. The disorder usually manifests clinically early after birth with abdominal distension, vomiting, feeding intolerance, and delayed passing of meconium. Diagnostic evaluation may include radiological studies; however, biopsy of colonic mucosa with histochemical analysis is considered the most reliable method. Manometry is a reliable noninvasive diagnostic study to confi rm motility disorder. Treatment may be medical in mild cases and more commonly surgical due to complications of the disorder. We present a case of immature colonic ganglion cells as a cause of megacolon in infancy. In our case, medicamentous treatment was eff ective and led to normalization of bowel emptying and stool consistency. Considering that follow up rectosigmoidoscopy was refused by the patient's parents, we were not able to compare the histopathologic fi ndings before and after the medicamentous treatment; however, the favorable clinical course made us assume that the ganglion cells had probably fully matured.en_US
dc.language.isoenen_US
dc.relation.ispartofPaediatria Croaticaen_US
dc.subjectcolonen_US
dc.subjectgangliaen_US
dc.subjectdygestive system abnormalitiesen_US
dc.subjectmegacolonen_US
dc.subjectinfanten_US
dc.titleImmature colonic ganglion cells as a cause of megacolon in infancy: Case reporten_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.13112/PC.2014.40-
dc.identifier.scopus2-s2.0-84923093464-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84923093464-
dc.description.versionPublisheden_US
dc.relation.lastpage230en_US
dc.relation.firstpage227en_US
dc.relation.issue3en_US
dc.relation.volume58en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptMedicinski fakultet, Katedra za patologiju-
crisitem.author.deptMedicinski fakultet, Katedra za histologiju i embriologiju-
crisitem.author.deptMedicinski fakultet, Katedra za internu medicinu-
crisitem.author.orcid0000-0002-8869-4806-
crisitem.author.orcid0000-0001-9250-959x-
crisitem.author.parentorgMedicinski fakultet-
crisitem.author.parentorgMedicinski fakultet-
crisitem.author.parentorgMedicinski fakultet-
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