Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/6547
DC Field | Value | Language |
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dc.contributor.author | Marković, Jelena | en_US |
dc.contributor.author | Uskoković A. | en_US |
dc.contributor.author | Grdović, Nevena | en_US |
dc.contributor.author | Dinić, Svetlana | en_US |
dc.contributor.author | Mihailović M. | en_US |
dc.contributor.author | Jovanović Arambašić, Jelena | en_US |
dc.contributor.author | Poznanović Goran | en_US |
dc.contributor.author | Vidaković, Melita | en_US |
dc.date.accessioned | 2019-09-30T08:55:47Z | - |
dc.date.available | 2019-09-30T08:55:47Z | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 08298211 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/6547 | - |
dc.description.abstract | © 2015 Published by NRC Research Press. Diabetes is characterized by a deficit in the number of functional pancreatic β-cells. Understanding the mechanisms that stimulate neogenesis of β-cells should contribute to improved maintenance of β-cell mass. Chemokine CXCL12 has recently become established as a novel β-cell growth factor, however the mechanisms controlling its expression require clarification. We investigated the proteins involved in the transcriptional regulation of the rat β-cell CXCL12 gene (Cxcl12). Using the electrophoretic mobility shift assay and chromatin immunoprecipitation, we established the in vitro and in vivo binding of C/EBPβ, C/EBPα, STAT3, p53, FOXO3a, and HMG I/Y to the Cxcl12 promoter. Co-immunoprecipitation experiments revealed protein-protein interactions between YY1 and PARP-1, FOXO3a and PARP-1, Sp1 and PARP-1, p53 and PARP-1, C/EBPβ and PARP-1, YY1 and p53, YY1 and FOXO3a, p53 and FOXO3a, Sp1 and FOXO3a, C/EBPβ and FOXO3a, C/EBPα and FOXO3a, Sp1 and STAT3. Our data lay the foundation for research into the interplay of signaling pathways that determine the β-cell Cxcl12 expression profile. | en |
dc.relation.ispartof | Biochemistry and Cell Biology | en |
dc.title | Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1139/bcb-2014-0104 | - |
dc.identifier.pmid | 93 | - |
dc.identifier.scopus | 2-s2.0-84921956361 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84921956361 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | 62 | en |
dc.relation.firstpage | 54 | en |
dc.relation.issue | 1 | en |
dc.relation.volume | 93 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Departman za biologiju i ekologiju | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | Naučne i umetničke publikacije |
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