Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/6389
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zorica Špirić | en_US |
dc.contributor.author | Živka Eri | en_US |
dc.contributor.author | Mirela Erić | en_US |
dc.date.accessioned | 2019-09-30T08:54:44Z | - |
dc.date.available | 2019-09-30T08:54:44Z | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 10668969 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/6389 | - |
dc.description.abstract | © The Author(s) 2015. Introduction. Induction of tumor lymphangiogenesis by vascular endothelial growth factor (VEGF)-C and VEGF-D promotes metastasis in many human cancers. Aim. The aim of this study was to examine the role of VEGF-C and VEGF-D in lymphangiogenesis and lymph node metastasis in patients with cutaneous melanoma. Materials and Methods. Fifty-four melanoma specimens (18 with lymph node metastasis, 36 nonmetastatic) were investigated by immunostaining for VEGF-C, VEGF-D, and for lymphatic endothelial marker D2-40. VEGF-C and VEGF-D expression was assessed as a percentage and intensity of stained tumor cells, tumor-associated macrophages and fibroblasts. The quantification of lymphangiogenesis was conducted by computer-assisted morphometric analysis. Results. The expressions of both VEGF-C and VEGF-D in tumor cells were significantly higher in lymph node metastatic melanomas compared with nonmetastatic melanomas (P =.015 VEGF-C; P =.005 VEGF-D). There was no statistically significant difference between metastatic and nonmetastatic melanomas regarding the expression of VEGF-C and VEGF-D in macrophages and fibroblasts. Metastatic melanomas showed a significantly higher intratumoral and peritumoral lymphatic vessel density (LVD) compared with nonmetastatic melanomas (P =.000 intratumoral, P =.000 peritumoral). Melanomas with VEGF-C positive tumor cells showed a significantly higher intratumoral and peritumoral LVD compared with VEGF-C negative tumor cells group of melanomas (P =.006 intratumoral, P =.010 peritumoral). VEGF-C expression in macrophages, fibroblasts, as well as VEGF-D expression in tumor cells, macrophages, and fibroblasts, showed no correlation with the intratumoral and peritumoral LVD. Conclusions. Our findings show the significance of VEGF-C in tumor cells in the induction of intratumoral and peritumoral lymphangiogenesis. This study suggests that both VEGF-C and VEGF-D in tumor cells promote lymph node metastasis, and that the immunohistochemical analysis of expression can be a useful tool for predicting clinical behavior of cutaneous melanoma. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | International Journal of Surgical Pathology | en_US |
dc.subject | VEGF-C | en_US |
dc.subject | VEGF-D | en_US |
dc.subject | lymph node metastasis | en_US |
dc.subject | lymphangiogenesis | en_US |
dc.subject | melanoma | en_US |
dc.title | Significance of vascular endothelial growth factor (VEGF)-C and VEGF-D in the progression of cutaneous melanoma | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1177/1066896915583694 | - |
dc.identifier.pmid | 23 | - |
dc.identifier.scopus | 2-s2.0-84947434933 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84947434933 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 637 | en_US |
dc.relation.firstpage | 629 | en_US |
dc.relation.issue | 8 | en_US |
dc.relation.volume | 23 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za anatomiju | - |
crisitem.author.orcid | 0000-0001-9214-384X | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
SCOPUSTM
Citations
24
checked on May 10, 2024
Page view(s)
20
Last Week
7
7
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.