Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/5315
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ana Cvetanović | en_US |
dc.contributor.author | Lazar Popović | en_US |
dc.contributor.author | Slađana Filipović | en_US |
dc.contributor.author | Jasna Trifunović | en_US |
dc.contributor.author | Nikola Živković | en_US |
dc.contributor.author | Gorana Matovina-Brko | en_US |
dc.contributor.author | Miloš Kostić | en_US |
dc.contributor.author | Ferenc Vicko | en_US |
dc.contributor.author | Biljana Kocić | en_US |
dc.contributor.author | Ivana Kolarov Bjelobrk | en_US |
dc.date.accessioned | 2019-09-30T08:47:11Z | - |
dc.date.available | 2019-09-30T08:47:11Z | - |
dc.date.issued | 2015-11-01 | - |
dc.identifier.issn | 11070625 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/5315 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate the influence of clinicopathological and biological characteristics on prognosis, disease free survival (DFS) and overall survival (OS), of very young patients (≤35 years of age) with breast cancer. Methods: We retrospectively collected information of 150 women diagnosed with breast cancer, aged ≤35 years, who were operated and treated at two University Hospitals in Serbia between January 2009 and February 2011. Results: After a median follow up of 44 months patients ≤30 had shorter DFS and OS compared to patients aged 31-35 years (p=0.004 and p=0.037, respectively). The differences in DFS and OS were significant with decreased survival associated with higher tumor grade (p=0.005 and p=0.0001, respectively). Tumor size and number of positive nodes were predictors of outcome with decreased survival associated withhigher tumor size (p=0.0019 for DFS and p<0.0001 for OS) and increasing number of nodes (p<0.0001 for both). HER 2 receptor did not seem to have a prognostic influence while patients with hormonal receptors (HRs) positive tumors had a better DFS (p=0.034) and OS (p=0.046) than those with HRs negative tumors. In univariate survival analysis, a significant difference in DFS (p=0.0003) and OS (p=0.0003) was found between patients with vs without lymphovascular invasion (LVI). Conclusion: Diagnosis of breast cancer at very young age (≤30) was associated with increased risk of death and shorter DFS than women aged 31-35. Negative impact on survival was seen in patients with presence of LVI, negative HRs and higher grade and stage at the time of presentation. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of B.U.ON. | en_US |
dc.subject | breast cancer | en_US |
dc.subject | Serbia | en_US |
dc.subject | 35 years-old | en_US |
dc.subject | young age | en_US |
dc.title | Young age and pathological features predict breast cancer outcome - Report from a dual Institution experience in Serbia | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.pmid | 20 | - |
dc.identifier.scopus | 2-s2.0-84960130408 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84960130408 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 1413 | en_US |
dc.relation.firstpage | 1407 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 20 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Katedra za onkologiju | - |
crisitem.author.dept | Katedra za internu medicinu | - |
crisitem.author.dept | Katedra za hirurgiju | - |
crisitem.author.dept | Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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