Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/4154
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Velibor Čabarkapa | en_US |
dc.contributor.author | Branislava Ilinčić | en_US |
dc.contributor.author | Mirjana Đerić | en_US |
dc.contributor.author | Viktorija Vučaj Ćirilov | en_US |
dc.contributor.author | Milena Kresoja | en_US |
dc.contributor.author | Radmila Žeravica | en_US |
dc.contributor.author | Vladimir Sakač | en_US |
dc.date.accessioned | 2019-09-23T10:32:17Z | - |
dc.date.available | 2019-09-23T10:32:17Z | - |
dc.date.issued | 2017-11-21 | - |
dc.identifier.issn | 0886022X | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/4154 | - |
dc.description.abstract | © 2016 The Author(s). Background: Biomarkers are commonly used to estimate the presence of subclinical cardiovascular disease (CVD) in patients with essential arterial hypertension (HT). In addition to known association between cystatin C and glomerular filtration rate (GFR), elucidating the association between cystatin C and vascular biomarkers (intima-media thickness of common carotid arteries (CCIMT), carotid plaque and renal artery resistance index (RRI)) in patients with unresponsive hypertensive phenotype could be of significant clinical interest. Methods: Participants (n=200, median age 58 (52-64) years, 49% female) under treatment with antihypertensive drugs were stratified into two subgroups based on their blood pressure level as having responsive hypertension (RHT-compliant and responsive to treatment, n=100), or nonresponsive (URHT-compliant but nonresponsive to treatment, n=100). GFR was measured by isotopic (slope-intercept) method (99m Tc diethylene triamine penta-acetic acid-mGFR). Results: The URHT group had significantly higher median cystatin C serum concentration (p=0.02) and CCIMT (p=0.00) compared to the RHT group, with no significant difference in RRI (p=0.51) and mGFR among subgroups [69.9±28.2 vs 76.74±23.61ml/min/1.73m2, p=0.27]. In the URHT group, cystatin C was found to be associated with CCIMT (p=0.02), hsCRP (p=0.01) and duration of HT (p=0.02), independently of mGFR and age. Independent predictors of URHT phenotype were CCIMT (p=0.02) and hsCRP (p=0.04). Conclusion: In addition to GFR, cystatin C serum concentration is positively and independently associated with CCIMT in patient with URHT phenotype and subclinical CVD. Prospective larger studies should further investigate the clinical importance of this relationship. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Renal Failure | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | subclinical tissue organ damage | en_US |
dc.subject | cardiovascular risk | en_US |
dc.subject | essential hypertension | en_US |
dc.subject | glomerular filtration rate | en_US |
dc.subject | cystatin C | en_US |
dc.title | Cystatin C, vascular biomarkers and measured glomerular filtration rate in patients with unresponsive hypertensive phenotype: A pilot study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1080/0886022X.2016.1256316 | - |
dc.identifier.pmid | 39 | - |
dc.identifier.scopus | 2-s2.0-84996635685 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84996635685 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 210 | en_US |
dc.relation.firstpage | 203 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 39 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patološku fiziologiju i laboratorijsku medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patološku fiziologiju i laboratorijsku medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za radiologiju | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za matematiku i informatiku | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patološku fiziologiju i laboratorijsku medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
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