Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/382
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ana Tomas Petrović | en_US |
dc.contributor.author | Nebojša Stilinović | en_US |
dc.contributor.author | Ana Sabo | en_US |
dc.contributor.author | Zdenko Tomić | en_US |
dc.date.accessioned | 2019-09-23T10:06:53Z | - |
dc.date.available | 2019-09-23T10:06:53Z | - |
dc.date.issued | 2019-04-01 | - |
dc.identifier.issn | 9280987 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/382 | - |
dc.description.abstract | Antibacterial drugs, including fluoroquinolones, can exert their therapeutic action only with adequate penetration at the infection site. Multiple factors, such as rate of protein binding, drug liposolubility and organ blood-flow all influence ability of antibiotics to penetrate target tissues. Microdialysis is an in vivo sampling technique that has been successfully applied to measure the distribution of fluoroquinolones in the interstitial fluid of different tissues both in animal studies and clinical setting. Tissue concentrations need to be interpreted within the context of the pathogenesis and causative agents implicated in infections. Integration of microdialysis -derived tissue pharmacokinetics with pharmacodynamic data offers crucial information for correlating exposure with antibacterial effect. This review explores these concepts and provides an overview of tissue concentrations of fluoroquinolones derived from microdialysis studies and explores the therapeutic implications of fluoroquinolone distribution at various target tissues. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European Journal of Pharmaceutical Sciences | en_US |
dc.subject | Fluoroquinolones | en_US |
dc.subject | Microdialysis | en_US |
dc.subject | Interstitial fluid | en_US |
dc.subject | Tissue penetration | en_US |
dc.subject | Pharmacokinetics | en_US |
dc.subject | Pharmacodynamics | en_US |
dc.title | Use of microdialysis for the assessment of fluoroquinolone pharmacokinetics in the clinical practice | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.ejps.2019.02.032 | - |
dc.identifier.pmid | 131 | - |
dc.identifier.scopus | 2-s2.0-85062077719 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85062077719 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 242 | en_US |
dc.relation.firstpage | 230 | en_US |
dc.relation.volume | 131 | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
Files in This Item:
File | Size | Format | |
---|---|---|---|
anatomas.pdf | 423.36 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
11
checked on May 10, 2024
Page view(s)
43
Last Week
13
13
Last month
0
0
checked on May 10, 2024
Download(s)
39
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.