Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32648
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nora Mihalek | en_US |
dc.contributor.author | Dragana Radovanović | en_US |
dc.contributor.author | Otto Barak | en_US |
dc.contributor.author | Petar Čolović | en_US |
dc.contributor.author | Markus Huber | en_US |
dc.contributor.author | Gabor Erdoes | en_US |
dc.date.accessioned | 2024-03-14T08:12:15Z | - |
dc.date.available | 2024-03-14T08:12:15Z | - |
dc.date.issued | 2023-08-09 | - |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32648 | - |
dc.description.abstract | Insight into the clinical potential of convalescent plasma in patients with coronavirus disease (COVID-19) is important given the severe clinical courses in unvaccinated and seronegative individuals. The aim of the study was to investigate whether there is a survival benefit of convalescent plasma therapy in COVID-19 patients. The authors independently assessed randomized controlled trials (RCTs) identified by the search strategy for inclusion, extracted data, and assessed risk of bias. The binary primary outcome was all-cause mortality. Risk ratio (RR) of the convalescent plasma treatment (vs. best standard care) and its associated standard error (effect size) were calculated. A random-effects model was employed to statistically pool the effect sizes of the selected studies. We included 19 RCTs with 17,021 patients. The random-effects model resulted in an estimated pooled RR of 0.94 (95% CI 0.81–1.08, p = 0.33), showing no statistical evidence of the benefit of convalescent plasma therapy on all-cause mortality. Convalescent plasma therapy was not found to be effective in reducing all-cause mortality in COVID-19 patients. Further studies are needed to determine in which patients convalescent plasma therapy may lead to a reduction in mortality. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Bias | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Immunization, Passive | en_US |
dc.subject | COVID-19 Serotherapy | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Convalescent plasma and all-cause mortality of COVID-19 patients: systematic review and meta-analysis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1038/s41598-023-40009-8 | - |
dc.identifier.pmid | 37558729 | - |
dc.identifier.scopus | 2-s2.0-85167533595 | - |
dc.identifier.isi | 001045574100033 | - |
dc.description.version | Published | en_US |
dc.relation.firstpage | 12904 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 13 | en_US |
local.message.claim | 2024-03-15T12:15:25.683+0100|||rp01798|||submit_approve|||publication-claimed-uncertain|||dc_contributor_author||| | * |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Katedra za anesteziju i perioperativnu medicinu | - |
crisitem.author.dept | Katedra za fiziologiju | - |
crisitem.author.dept | Odsek za psihologiju | - |
crisitem.author.orcid | 0000-0001-6727-8304 | - |
crisitem.author.orcid | 0000-0003-1212-3131 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Filozofski fakultet | - |
Appears in Collections: | FF Publikacije/Publications |
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File | Description | Size | Format | |
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s41598-023-40009-8.pdf | 2.22 MB | Adobe PDF | View/Open |
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