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Title: Quantitative behavioral genetic and molecular genetic foundations of the approach and avoidance strategies
Authors: Smederevac Snežana 
Sadiković Selka 
Čolović Petar 
Vučinić Nataša 
Milutinović Aleksandra 
Riemann Rainer
Corr Philip J.
Prinz Mechthild
Budimlija Zoran
Keywords: Approach, Avoidance, DRD2, COMT, TPH2
Issue Date: 2022
Publisher: Springer Nature
Project: This research was supported by the Science Fund of the Republic of Serbia (#7744418 GENIUS) and the German Research Foundation (DFG) (#220286500).
Journal: Current Psychology
Abstract: Two studies examined genetic and environmental influences on traits proposed by the revised Reinforcement Sensitivity Theory (rRST) of personality. Both quantitative and molecular behavioral genetic methods were applied considering the effects of COMT, DRD2, HTR1A and TPH2 single nucleotide polymorphisms (SNPs). Study one included 274 monozy- gotic and 154 dizygotic twins for the quantitative behavioral study; and in study two there were 431 twins for the molecular genetic study. The Reinforcement Sensitivity Questionnaire was used to assess basic personality traits defined by the rRST. Univariate biometric modeling suggested that genetic influences accounted for 34–44% of variance of Behavioral Approach System (BAS), Behavioral Inhibition System (BIS) and Fight-Fligh-Freeze System. Molecular genetic analyses proposed the significant main effect of COMT SNP on the BAS and TPH2 SNP on the BIS, and pointed out epistatic effects of COMT x DRD2 on BAS and HTR1A x TPH2 on Fight. Results demonstrated substantial heritability for all rRST constructs, as well as for differences in the molecular genetic basis of both approach-related and avoidance-related dimensions.
ISSN: 19364733
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States
Appears in Collections:FF Publikacije/Publications

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