Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/32477
Title: Bioactive scaffold (sodium alginate)-g-(nHAp@SiO2@GO) for bone tissue engineering
Authors: Muhammad Umar Aslam Khan
Saiful Izwan Abd Razak
Sarish Rehman
Anwarul Hasan
Saima Qureshi
Goran Stojanović 
Keywords: Biodegradation;Bone scaffold;Nanotechnology;Osteoconductivity;Tissue engineering;Biopolymer
Issue Date: 23-Sep-2022
Publisher: Elsevier
Project: GREENELIT
Journal: International Journal of Biological Macromolecules
Abstract: Globally, people suffering from bone disorders are steadily increasing and bone tissue engineering is an advanced approach to treating fractured and defected bone tissues. In this study, we have prepared polymeric nanocomposite by free-radical polymerization from sodium alginate, hydroxyapatite, and silica with different GO amounts. The porous scaffolds were fabricated using the freeze drying technique. The structural, morphological, mechanical, and wetting investigation was conducted by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscope, universal tensile machine, and water contact angle characterization techniques. The swelling, biodegradation, and water retention were also studied. The biological studies were performed (cell viability, cell adherence, proliferation, and mineralization) against osteoblast cell lines. Scaffolds have exhibited different pore morphology SAG-1 (pore size = 414.61 ± 56 μm and porosity = 81.45 ± 2.17 %) and SAG-4 (pore size = 195.97 ± 82 μm and porosity = 53.82 ± 2.45 %). They have different mechanical behavior as SAG-1 has the least compression strength and compression modulus 2.14 ± 2.35 and 16.51 ± 1.27 MPa. However, SAG-4 has maximum compression strength and compression modulus 13.67 ± 2.63 and 96.16 ± 1.97 MPa with wetting behavior 80.70◦ and 58.70◦, respectively. Similarly, SAG-1 exhibited the least and SAG-4 presented maximum apatite mineral formation, cell adherence, cell viability, and cell proliferation against mouse pre-osteoblast cell lines. The increased GO amount provides different multifunctional materials with different characteristics. Hence, the fabricated scaffolds could be potential scaffold materials to treat and regenerate fracture bone tissues in bone tissue engineering.
URI: https://open.uns.ac.rs/handle/123456789/32477
ISSN: 0141-8130
DOI: https://doi.org/10.1016/j.ijbiomac.2022.09.153
Rights: Attribution-NonCommercial-NoDerivs 3.0 United States
Appears in Collections:FTN Publikacije/Publications

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