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https://open.uns.ac.rs/handle/123456789/32383
Поље DC-а | Вредност | Језик |
---|---|---|
dc.contributor.author | Kovačević Ivana | - |
dc.contributor.author | Popsavin Mirjana | - |
dc.contributor.author | Benedeković Goran | - |
dc.contributor.author | Kojić Vesna | - |
dc.contributor.author | Jakimov Dimitar | - |
dc.contributor.author | Rodić Marko | - |
dc.contributor.author | Srdić Rajić Tatjana | - |
dc.contributor.author | Bogdanović Gordana | - |
dc.contributor.author | Divjaković Vladimir | - |
dc.contributor.author | Popsavin Velimir | - |
dc.date.accessioned | 2020-12-14T21:36:52Z | - |
dc.date.available | 2020-12-14T21:36:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32383 | - |
dc.description.abstract | © 2015 Elsevier Masson SAS. A new synthesis of goniobutenolides A (1) and B (2) and the corresponding 7-epimers has been achieved starting from diacetone d-glucose. The key step of the synthesis is a new one-pot sequence that commenced with Z-selective Wittig (or Horner-Wadsworth-Emmons) olefination, followed by successive γ-lactonisation and β-elimination. The above-mentioned unsaturated lactones were then converted to the corresponding 5-halogenated crassalactone D derivatives by using the appropriate haloetherification protocol. The most of synthesized compounds exhibited potent cytotoxic activities against a panel of tumour cell lines. The main structural features responsible for their antitumour potency have been revealed by means of SAR analysis. Flow cytometry data suggested that cytotoxic effects of these compounds in the culture of K562 cells might be mediated by apoptosis, additionally revealing that these molecules induced changes in cell cycle distribution of these cells. Results of semi-quantitative Western blot analysis indicate that the most of synthesized compounds induce apoptosis in a caspase-dependent manner. | - |
dc.language.iso | en | - |
dc.relation.ispartof | European Journal of Medicinal Chemistry | - |
dc.source | CRIS UNS | - |
dc.source.uri | http://cris.uns.ac.rs | - |
dc.title | Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers | - |
dc.type | Journal/Magazine Article | - |
dc.identifier.doi | 10.1016/j.ejmech.2015.12.011 | - |
dc.identifier.pmid | 108 | - |
dc.identifier.scopus | 2-s2.0-84951299322 | - |
dc.identifier.url | https://www.cris.uns.ac.rs/record.jsf?recordId=99981&source=BEOPEN&language=en | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84951299322 | - |
dc.relation.lastpage | 604 | - |
dc.relation.firstpage | 594 | - |
dc.relation.volume | 108 | - |
dc.identifier.externalcrisreference | (BISIS)99981 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Medicinski fakultet | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.dept | Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.orcid | 0000-0002-0924-1041 | - |
crisitem.author.orcid | 0000-0002-4752-7569 | - |
crisitem.author.orcid | 0000-0002-4471-8001 | - |
crisitem.author.orcid | 0000-0001-9910-2987 | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Налази се у колекцијама: | PMF Publikacije/Publications |
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