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https://open.uns.ac.rs/handle/123456789/32342
Title: | Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy | Authors: | Knežević, Nikola Mrđanović, Jasminka Borišev, Ivana Milenković, Sanja Janaćković, Đorđe Cunin, Frédérique Đorđević, Aleksandar |
Issue Date: | Jan-2016 | Publisher: | The Royal Society of Chemistry | Journal: | RSC Advances | Abstract: | A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-overexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces. | URI: | https://open.uns.ac.rs/handle/123456789/32342 | ISSN: | 2046-2069 | DOI: | 10.1039/C5RA22937E (BISIS)99883 |
Appears in Collections: | IBS Publikacije/Publications |
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