Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/3125
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mihalj Poša | en_US |
dc.contributor.author | Ana Pilipović | en_US |
dc.date.accessioned | 2019-09-23T10:25:50Z | - |
dc.date.available | 2019-09-23T10:25:50Z | - |
dc.date.issued | 2017-07-01 | - |
dc.identifier.issn | 1677322 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/3125 | - |
dc.description.abstract | © 2017 Elsevier B.V. Hyodeoxycholic acids anion (HD) and it's 3- and 6-epimers (3e-HD and 6e-HD) are suitable for biopharmaceutical application since they possess α equatorial i.e. β axial OH groups so their membranotoxicity is reduced. Self-association of stereoisomers 3e-HD and 6e-HD has not been studied so far. According to the capacity factor (k, RPHPLC), hydrophobicity decreases in the following series: HD > 3e-HD > 6e-HD. However, critical micelle concentration (CMC) is the lowest for the 6e-HD (10 mM, 25 °C) and the highest for 3e-HD (38 mM, 25 °C), which is contrary to expectations according to their hydrophobicity. Aggregation number (n) has the highest value for 6e-HD (8, 25 °C) and the lowest value for the stereoisomer 3e-HD (4, 25 °C). The change in demicellisation capacity factor (∆ Cp) decreases in the following series: 6e-HD (316 J mol− 1 K− 1) > HD (260 J mol− 1 K− 1) > 3e-HD (181 J mol− 1 K− 1). In the plane of ln k – ln CMC epimer 6e-HD is outliner related to the hydrophobic congeneric group. This suggests that, in formation of micelles of HD and 3e-HD, besides hydrophobic effect other interactions are neglected. However, in formation of 6e-HD micelle, beside hydrophobic effect significant interaction exists different from hydrophobic interaction (formation of hydrogen bonds between building units of the micelle). | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Molecular Liquids | en_US |
dc.subject | Bile acids | en_US |
dc.subject | Steroid skeleton | en_US |
dc.subject | Micelle | en_US |
dc.subject | Conformational analysis | en_US |
dc.subject | Hydrophobic effect | en_US |
dc.title | Self-association of C3 and C6 epimers of hyodeoxycholate anions in aqueous medium: Hydrophobicity, critical micelle concentration and aggregation number | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.molliq.2017.04.109 | - |
dc.identifier.scopus | 2-s2.0-85019011563 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85019011563 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 57 | en_US |
dc.relation.firstpage | 48 | en_US |
dc.relation.volume | 238 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.orcid | 0000-0002-8044-2655 | - |
crisitem.author.orcid | 0000-0001-8589-2877 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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