Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/3125
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dc.contributor.authorMihalj Pošaen_US
dc.contributor.authorAna Pilipovićen_US
dc.date.accessioned2019-09-23T10:25:50Z-
dc.date.available2019-09-23T10:25:50Z-
dc.date.issued2017-07-01-
dc.identifier.issn1677322en_US
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/3125-
dc.description.abstract© 2017 Elsevier B.V. Hyodeoxycholic acids anion (HD) and it's 3- and 6-epimers (3e-HD and 6e-HD) are suitable for biopharmaceutical application since they possess α equatorial i.e. β axial OH groups so their membranotoxicity is reduced. Self-association of stereoisomers 3e-HD and 6e-HD has not been studied so far. According to the capacity factor (k, RPHPLC), hydrophobicity decreases in the following series: HD > 3e-HD > 6e-HD. However, critical micelle concentration (CMC) is the lowest for the 6e-HD (10 mM, 25 °C) and the highest for 3e-HD (38 mM, 25 °C), which is contrary to expectations according to their hydrophobicity. Aggregation number (n) has the highest value for 6e-HD (8, 25 °C) and the lowest value for the stereoisomer 3e-HD (4, 25 °C). The change in demicellisation capacity factor (∆ Cp) decreases in the following series: 6e-HD (316 J mol− 1 K− 1) > HD (260 J mol− 1 K− 1) > 3e-HD (181 J mol− 1 K− 1). In the plane of ln k – ln CMC epimer 6e-HD is outliner related to the hydrophobic congeneric group. This suggests that, in formation of micelles of HD and 3e-HD, besides hydrophobic effect other interactions are neglected. However, in formation of 6e-HD micelle, beside hydrophobic effect significant interaction exists different from hydrophobic interaction (formation of hydrogen bonds between building units of the micelle).en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Molecular Liquidsen_US
dc.subjectBile acidsen_US
dc.subjectSteroid skeletonen_US
dc.subjectMicelleen_US
dc.subjectConformational analysisen_US
dc.subjectHydrophobic effecten_US
dc.titleSelf-association of C3 and C6 epimers of hyodeoxycholate anions in aqueous medium: Hydrophobicity, critical micelle concentration and aggregation numberen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.1016/j.molliq.2017.04.109-
dc.identifier.scopus2-s2.0-85019011563-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85019011563-
dc.description.versionPublisheden_US
dc.relation.lastpage57en_US
dc.relation.firstpage48en_US
dc.relation.volume238en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptMedicinski fakultet, Katedra za farmaciju-
crisitem.author.deptMedicinski fakultet, Katedra za farmaciju-
crisitem.author.orcid0000-0002-8044-2655-
crisitem.author.orcid0000-0001-8589-2877-
crisitem.author.parentorgMedicinski fakultet-
crisitem.author.parentorgMedicinski fakultet-
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