Complexes of Co(III), Ni(II) and Cu(II) with hydrazones of some 2-pyridyl-ke-tones

Abstract

<p><br />U disertaciji su opisane sinteze i fizičko-hemijske karakterizacije 32 kompleksa kobalta(III), nikla(II) i bakra(II) sa ligandima S-metilizotiosemikarbazonom 2-acetilpiridina (HL&sup1;), bis(S-metilizotiosemikarbazonom) 2,6-diacetilpiridina (H₂L&sup2;), tiosemikarbazonom-S-metilizotiosemikarbazonom 2,6-diacetilpiridina (HL&sup3;), 1-adamantoilhidrazonom 2-acetilpiridina (HL⁴) i 1-adamantoilhidrazonom di(2-piridil)-ketona (HL⁵).</p><p>Kako ligandi HL&sup3;, HL⁴ i HL⁵ do sada nisu bili sintetisani, dobijeni rezultati ujedno predstavljaju i prve iz njihove koordinacione hemije. Iako je sa S-metilizotiosemikarbazonom 2-acetilpiridina poznato nekoliko kompleksa, do sada nijedan od njih nije strukturno okarakterisan, tako da su rezultati prikazani u ovoj disertaciji dali jasnu sliku o načinima koordinacije HL&sup1;. Takođe, kako je sa H₂L&sup2; poznat vrlo malo broj kompleksa, dobijeni rezultati su dali značajan doprinos razumevanju koordinacione hemije ovog liganda.</p><p>Gotovo svi sintetisani kompleksi (njih 27 od 32) su strukturno okarakterisani metodom rendgenske kristalografije. Odabrana jedinjenja su ispitana metodama termičke analize, a utvrđena je njihova antimikrobna i citotoksična aktivnost.</p><p>&nbsp;</p>

<p>This thesis describes syntheses and physico-chemical characterizations of 32 complexes of cobalt(III), nickel(II) and copper(II), with ligands 2-acetylpyridine S-methylisothiosemicarbazone (HL&sup1;), 2,6-dicetylpyridine bis(S-methylisothiosemicarbazone) (H₂L&sup2;), thiosemicarbazone-S-methylisothiosemicarbazone 2,6-dicetylpyridine (HL&sup3;), 2-acetylpyridine 1-adamantoylhydrazone (HL⁴), and di(2-pyridil)-ketone 1-adamantoylhydrazone (HL⁵).</p><p>Since the ligands HL&sup3;, HL⁴, and HL⁵ were not synthetized hitherto, the obtained results are the first regarding their coordination chemistry as well. Even though there are several complexes reported with 2-acetylpyridine S-methylisothiosemicarbazone as a ligand, none of them was structurally characterized. Therefore, here presented results gave clear insight into coordination modes of the HL&sup1;. Moreover, since there is limited number of complexes with H₂L&sup2; reported hitherto, the obtained results gave significant contribution to understanding of its coordination chemistry.</p><p>Almost each synthetized complex (27 out of 32) was structurally characterized by means of single crystal X-ray crystallography. The selected compounds were characterized by thermal analysis, and their antimicrobial and cytotoxic activity were determined.</p>