Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/3071
DC Field | Value | Language |
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dc.contributor.author | Noc M. | en_US |
dc.contributor.author | Erlinge D. | en_US |
dc.contributor.author | Neskovic A. | en_US |
dc.contributor.author | Kafedzic S. | en_US |
dc.contributor.author | Merkely B. | en_US |
dc.contributor.author | Zima E. | en_US |
dc.contributor.author | Fister M. | en_US |
dc.contributor.author | Petrović, Milovan | en_US |
dc.contributor.author | Čanković, Milenko | en_US |
dc.contributor.author | Veress G. | en_US |
dc.contributor.author | Laanmets P. | en_US |
dc.contributor.author | Pern T. | en_US |
dc.contributor.author | Vukčević, V. | en_US |
dc.contributor.author | Dedović, Vladimir | en_US |
dc.contributor.author | Średniawa B. | en_US |
dc.contributor.author | Światkowski A. | en_US |
dc.contributor.author | Keeble T. | en_US |
dc.contributor.author | Davies J. | en_US |
dc.contributor.author | Warenits A. | en_US |
dc.contributor.author | Olivecrona G. | en_US |
dc.contributor.author | Peruga J. | en_US |
dc.contributor.author | Ciszewski M. | en_US |
dc.contributor.author | Horvath I. | en_US |
dc.contributor.author | Edes I. | en_US |
dc.contributor.author | Nagy G. | en_US |
dc.contributor.author | Aradi D. | en_US |
dc.contributor.author | Holzer M. | en_US |
dc.date.accessioned | 2019-09-23T10:25:31Z | - |
dc.date.available | 2019-09-23T10:25:31Z | - |
dc.date.issued | 2017-08-01 | - |
dc.identifier.issn | 1774024X | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/3071 | - |
dc.description.abstract | © Europa Digital & Publishing 2017. All rights reserved. Aims: We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest. Methods and results: A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20.5 minutes of endovascular cooling decreased to 33.6°C (range 31.9-35.5°C). There was a 17-minute (95% CI: 4.6-29.8 min) cooling-related delay to reperfusion. In "per protocol" analysis, median infarct size/left ventricular mass was 16.7% in the hypothermia group versus 23.8% in the control group (absolute reduction 7.1%, relative reduction 30%; p=0.31) and median left ventricular ejection fraction (LVEF) was 42% in the hypothermia group and 40% in the control group (absolute reduction 2.4%, relative reduction 6%; p=0.36). Except for self-terminating paroxysmal atrial fibrillation (32% versus 8%; p=0.074), there was no excess of adverse events in the hypothermia group. Conclusions: We rapidly and safely cooled patients with anterior STEMI to 33.6°C at the time of coronary guidewire crossing. This is ≥1.1°C lower than in previous cooling studies. Except for self-terminating atrial fibrillation, there was no excess of adverse events and no clinically important cooling-related delay to reperfusion. A statistically non-significant numerical 7.1% absolute and 30% relative reduction in infarct size warrants a pivotal trial powered for efficacy. | en |
dc.relation.ispartof | EuroIntervention | en |
dc.title | COOL AMI EU pilot trial: A multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.4244/EIJ-D-17-00279 | - |
dc.identifier.scopus | 2-s2.0-85027222792 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85027222792 | - |
dc.description.version | Unknown | en_US |
dc.relation.lastpage | e539 | en |
dc.relation.firstpage | e531 | en |
dc.relation.issue | 5 | en |
dc.relation.volume | 13 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.dept | Medicinski fakultet, Katedra za internu medicinu | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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